• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Defining the biological responses of IL-6 by the study of a novel IL-6 receptor chain immunodeficiency.

作者信息

Nahum Amit, Sharfe Nigel, Broides Arnon, Dadi Harjit, Naghdi Zahra, Mandola Amarilla B, Vong Linda, Arbiv Adi, Dalal Ilan, Brami Ido, Wormser Ohad, Levy Jacov, Roifman Chaim M

机构信息

Pediatrics Department A, Soroka University Medical Center, Be'er Sheva, Israel; Immunology Clinic, Soroka University Medical Center, Be'er Sheva, Israel; Primary Immunodeficiency Research Laboratory, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel.

Canadian Centre for Primary Immunodeficiency and the Jeffrey Modell Research Laboratory for the Diagnosis of Primary Immunodeficiency, the Hospital for Sick Children, Toronto, Ontario, Canada; Division of Immunology and Allergy, Department of Paediatrics, the Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.

出版信息

J Allergy Clin Immunol. 2020 Mar;145(3):1011-1015.e6. doi: 10.1016/j.jaci.2019.11.015. Epub 2019 Nov 26.

DOI:10.1016/j.jaci.2019.11.015
PMID:31778705
Abstract
摘要

相似文献

1
Defining the biological responses of IL-6 by the study of a novel IL-6 receptor chain immunodeficiency.通过研究一种新型白细胞介素-6受体链免疫缺陷来定义白细胞介素-6的生物学反应。
J Allergy Clin Immunol. 2020 Mar;145(3):1011-1015.e6. doi: 10.1016/j.jaci.2019.11.015. Epub 2019 Nov 26.
2
A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency.RAC2基因中的单等位基因激活突变导致联合免疫缺陷。
J Allergy Clin Immunol. 2019 Apr;143(4):1649-1653.e3. doi: 10.1016/j.jaci.2019.01.001. Epub 2019 Jan 14.
3
Genesis of progressive T-cell deficiency owing to a single missense mutation in the common gamma chain gene.由于常见γ链基因中的单个错义突变导致进行性T细胞缺陷的发生机制。
Scand J Immunol. 2001 Dec;54(6):582-91. doi: 10.1046/j.1365-3083.2001.01006.x.
4
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.白细胞介素-6 受体缺失导致免疫缺陷、过敏症和异常炎症反应。
J Exp Med. 2019 Sep 2;216(9):1986-1998. doi: 10.1084/jem.20190344. Epub 2019 Jun 24.
5
Novel MALT1 Mutation Linked to Immunodeficiency, Immune Dysregulation, and an Abnormal T Cell Receptor Repertoire.新型 MALT1 突变与免疫缺陷、免疫失调和异常 T 细胞受体库相关。
J Clin Immunol. 2019 May;39(4):401-413. doi: 10.1007/s10875-019-00629-0. Epub 2019 Apr 29.
6
Recurrent Respiratory Infections Revealing CD8α Deficiency.反复呼吸道感染揭示 CD8α 缺陷。
J Clin Immunol. 2015 Nov;35(8):692-5. doi: 10.1007/s10875-015-0213-x. Epub 2015 Nov 12.
7
Two hits in one: whole genome sequencing unveils LIG4 syndrome and urofacial syndrome in a case report of a child with complex phenotype.一箭双雕：全基因组测序在一名具有复杂表型儿童的病例报告中揭示了LIG4综合征和泌尿生殖面综合征。
BMC Med Genet. 2016 Nov 17;17(1):84. doi: 10.1186/s12881-016-0346-7.
8
Simultaneous presentation of 2 rare hereditary immunodeficiencies: IL-12 receptor beta1 deficiency and ataxia-telangiectasia.同时呈现两种罕见的遗传性免疫缺陷：白细胞介素-12受体β1缺陷和共济失调毛细血管扩张症。
J Allergy Clin Immunol. 2008 Dec;122(6):1217-9. doi: 10.1016/j.jaci.2008.07.005. Epub 2008 Aug 20.
9
Evaluation of interleukin-12 receptor β1 and interferon gamma receptor 1 deficiency in patients with disseminated BCG infection.播散性卡介苗感染患者白细胞介素-12受体β1和干扰素γ受体1缺陷的评估。
Allergol Immunopathol (Madr). 2019 Jan-Feb;47(1):38-42. doi: 10.1016/j.aller.2018.06.005. Epub 2018 Sep 27.
10
Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.常染色体隐性 LCK 缺陷导致的原发性 T 细胞免疫缺陷伴免疫调节紊乱。
J Allergy Clin Immunol. 2012 Nov;130(5):1144-1152.e11. doi: 10.1016/j.jaci.2012.07.029. Epub 2012 Sep 15.

引用本文的文献

1
Cytokine signaling defects in primary atopic diseases-an updated review.原发性特应性疾病中的细胞因子信号传导缺陷——最新综述
Front Allergy. 2025 Jul 1;6:1617714. doi: 10.3389/falgy.2025.1617714. eCollection 2025.
2
Pathological IgE Production in Inborn Errors of Immunity and Beyond.免疫先天性疾病及其他情况下的病理性IgE产生
Immunol Rev. 2025 Jul;332(1):e70053. doi: 10.1111/imr.70053.
3
IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention.免疫病理学中的白细胞介素-6信号传导：从基础生物学到选择性治疗干预
Immunotargets Ther. 2025 Jul 5;14:681-695. doi: 10.2147/ITT.S485684. eCollection 2025.
4
The genetics of hyper IgE syndromes.高免疫球蛋白E综合征的遗传学
Front Immunol. 2025 Feb 18;16:1516068. doi: 10.3389/fimmu.2025.1516068. eCollection 2025.
5
The monogenic landscape of human infectious diseases.人类传染病的单基因格局。
J Allergy Clin Immunol. 2025 Mar;155(3):768-783. doi: 10.1016/j.jaci.2024.12.1078. Epub 2024 Dec 24.
6
The ouroboros of autoimmunity.自身免疫的衔尾蛇。
Nat Immunol. 2024 May;25(5):743-754. doi: 10.1038/s41590-024-01815-y. Epub 2024 May 2.
7
COMMON VARIABLE IMMUNODEFICIENCY: PREDISPOSING OR PROTECTIVE FACTOR FOR SEVERE COMPLICATIONS OF COVID-19?常见可变免疫缺陷：是 COVID-19 严重并发症的诱发因素还是保护因素？
Acta Clin Croat. 2022 Mar;61(1):107-114. doi: 10.20471/acc.2022.61.01.13.
8
Inborn Errors of the Immune System Associated With Atopy.与过敏相关的先天性免疫系统错误。
Front Immunol. 2022 Apr 27;13:860821. doi: 10.3389/fimmu.2022.860821. eCollection 2022.
9
Human autoantibodies underlying infectious diseases.人体感染性疾病相关的自身抗体。
J Exp Med. 2022 Apr 4;219(4). doi: 10.1084/jem.20211387. Epub 2022 Mar 23.
10
Inborn errors of IL-6 family cytokine responses.白细胞介素 6 家族细胞因子反应的先天性错误。
Curr Opin Immunol. 2021 Oct;72:135-145. doi: 10.1016/j.coi.2021.04.007. Epub 2021 May 24.