微环境在 MDS 中扮演什么角色？
What is the role of the microenvironment in MDS?
机构信息
University of Rochester School of Medicine, Wilmot Cancer Institute, 601 Elmwood Avenue, Box 794, Rochester, NY, 14642, USA.
University of Rochester School of Medicine, Wilmot Cancer Institute, 601 Elmwood Avenue, Box 794, Rochester, NY, 14642, USA.
出版信息
Best Pract Res Clin Haematol. 2019 Dec;32(4):101113. doi: 10.1016/j.beha.2019.101113. Epub 2019 Oct 28.
Treating myelodysplastic syndromes (MDS) remains challenging. Hematopoiesis occurs within a heterogeneous, complex and dynamic microenvironment, and a multiplicity of mutations in hematopoietic stem and progenitor cells (HSPCs) lead to MDS. But is there a role for the microenvironment? Here we review experimental and conceptual arguments that support a role for the microenvironment, provide evidence for the disruption of the microenvironment in MDS, and explore microenvironmental signals that may provide a targetable and conserved vulnerability in MDS that transcend genetic heterogeneity.
治疗骨髓增生异常综合征 (MDS) 仍然具有挑战性。造血发生在一个异质、复杂和动态的微环境中，造血干细胞和祖细胞 (HSPC) 中的多种突变导致 MDS。但是微环境是否起作用呢？在这里，我们回顾了支持微环境起作用的实验和概念性论据，提供了 MDS 中微环境破坏的证据，并探讨了可能为 MDS 提供可靶向和保守弱点的微环境信号，这些弱点超越了遗传异质性。
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