Sandros J, Mark J, Happonen R P, Stenman G
Department of Oral Pathology, Gothenburg University, Sweden.
Anticancer Res. 1988 Jul-Aug;8(4):637-43.
The chromosomal banding patterns in 20 human malignant salivary gland tumors are reported. Abnormal stem-and/or sidelines were observed in 14 cases, and abnormal clones and variant cells in the remaining 6 cases. No less than 8 tumors showed clonal rearrangements involving the long arm of chromosome 6, i.e. terminal deletions with breakpoints in the 6q22-25 region. The possible involvement of c-myb or a putative tumor suppressor gene in the 6q deletions is considered. Other recurrent deviations were loss of the Y chromosome, trisomy 8 and 11q- markers. The combined data from this and previous studies show that most of the rearrangements are not restricted to a certain type of malignant salivary gland tumor, but are seen in several tumor types, indicating a close evolutionary relationship between different malignant salivary gland tumors.
本文报道了20例人类恶性涎腺肿瘤的染色体带型。14例观察到异常的干系和/或旁系，其余6例观察到异常克隆和变异细胞。不少于8例肿瘤显示涉及6号染色体长臂的克隆重排，即6q22 - 25区域有断点的末端缺失。考虑了c-myb或6q缺失中一个假定的肿瘤抑制基因可能的参与情况。其他常见的异常包括Y染色体丢失、8三体和11q-标记。这项研究和以往研究的综合数据表明，大多数重排并不局限于某一类型的恶性涎腺肿瘤，而是在几种肿瘤类型中都可见到，这表明不同恶性涎腺肿瘤之间存在密切的进化关系。
