Fortmeyer H P, Timm C, Blum U, Wenisch H J, Förster H
TVA, J.W. Goethe-Universität Frankfurt/Main, F.R.G.
Anticancer Res. 1988 Jul-Aug;8(4):813-8.
The model of human malignant tumors, heterotransplanted and passaged into athymic nude mice, proved to be a valuable tool for nutritional oncology. It showed that several human tumors proliferate in distinct dependence on the available vitamin B6. A surplus of the vitamin causes enhancement of growth. Proliferation is retarded in cases of reduced availability. The amount of vitamin B6 available does not only depend on the dietary supply. The contribution of the intestinal flora may be considerable. Therefore the adverse effect of a diet free of vitamin B6 is distinctly increased by additional application of a vitamin antagonist such as D-penicillamine for instance. It should be emphasized that this happens even in situations in which no clinical symptoms of vitamin deficiency could be observed at all. Our experimental findings may have consequences for those human patients who are stricken with vitamin B6 responsive tumors. A shifting supply of vitamin B6 should at least be avoided. Dietary guidance and a careful use of vitamin antagonists, such as D-penicillamine for instance, may be helpful.
将人类恶性肿瘤异种移植并传代至无胸腺裸鼠体内的模型，被证明是营养肿瘤学的一种有价值的工具。研究表明，几种人类肿瘤的增殖明显依赖于可用的维生素B6。维生素过剩会导致生长增强。在可用性降低的情况下，增殖会受到抑制。可用的维生素B6量不仅取决于饮食供应。肠道菌群的贡献可能相当大。因此，通过额外施用维生素拮抗剂（如D-青霉胺），无维生素B6饮食的不利影响会明显增加。应该强调的是，即使在完全没有观察到维生素缺乏临床症状的情况下，这种情况也会发生。我们的实验结果可能会对患有维生素B6反应性肿瘤的人类患者产生影响。至少应避免维生素B6供应的波动。饮食指导和谨慎使用维生素拮抗剂（如D-青霉胺）可能会有所帮助。
