Biophysics Unit, Department of Biochemistry and Molecular Biology, School of Medicine, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Catalonia, Spain.
Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain.
Biomolecules. 2019 Nov 27;9(12):791. doi: 10.3390/biom9120791.
Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein-protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments.
瞬时受体电位阳离子通道正在成为重要的生理和治疗靶点。在香草素亚家族中，瞬时受体电位香草素 2（TRPV2）和 4（TRPV4）是渗透压和机械感受器，成为细胞结构和功能的关键决定因素。然而，关于 TRPV2 和 TRPV4 如何转运到质膜或特定细胞器，以及通过生物合成、顺行/逆行转运和再循环等过程进行质量控制的知识还很匮乏。这篇综述列出并回顾了 TRPV2 和 TRPV4 相互作用组中的一组蛋白质-蛋白质相互作用，这些相互作用与脂质代谢、磷酸肌醇信号转导、囊泡介导的运输以及与突触相关的胞吐等转运过程有关。鉴定参与转运的蛋白质和脂质成分将有助于提高对这些与伸展相关的通道如何到达特定细胞区室的认识。
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