Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
Cells. 2021 Jan 15;10(1):165. doi: 10.3390/cells10010165.
The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated by a range of post-translational modifications, the majority of which we are only just beginning to understand. Not surprisingly, a great number of physiological roles have emerged for TRPV4, as have various disease states that are attributable to the absence, or abnormal functioning, of this ion channel. This review will highlight structural features of TRPV4, endogenous and exogenous activators of the channel, and discuss the reported roles of TRPV4 in health and disease.
瞬时受体电位香草酸受体 4 通道（TRPV4）属于哺乳动物 TRP 阳离子通道超家族。TRPV4 广泛表达，可被多种刺激激活，与多种蛋白质相互作用，并受多种翻译后修饰的调节，其中大部分我们才刚刚开始了解。毫不奇怪，TRPV4 出现了许多生理作用，也出现了许多归因于该离子通道缺失或功能异常的疾病状态。本综述将重点介绍 TRPV4 的结构特征、通道的内源性和外源性激活剂，并讨论 TRPV4 在健康和疾病中的报道作用。
