Department of Surgical-Pathology/Hematopathology, Saint'Eugenio Hospital, Rome, Italy.
Hematology Unit, Saint' Eugenio Hospital, Rome, Italy.
Pathol Res Pract. 2020 Feb;216(2):152724. doi: 10.1016/j.prp.2019.152724. Epub 2019 Oct 31.
Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking "Hodgkin-like" cytomorphology and a very uncommon nuclear expression of PAX5.
间变性大细胞淋巴瘤，ALK 阴性（ALK-ALCL）是一种 CD30+ T 细胞恶性淋巴瘤，可累及淋巴结和结外组织，与间变性大细胞淋巴瘤，ALK 阳性（ALK+ALCL）相比具有重要的临床差异。ALK-ALCL 在 2016 年世界卫生组织（WHO）血液淋巴肿瘤分类中被认为是一种特殊实体。我们描述了一例罕见的 ALK-ALCL 病例，其具有显著的“霍奇金样”细胞形态学特征和非常罕见的 PAX5 核表达。
