进食高碳水化合物零食后，年轻健康志愿者的全身内皮依赖性微血管反应性增加。
Increased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteers.
机构信息
National Institute of Cardiology, Rio de Janeiro, Brazil; Heart Institute Edson Saad, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
National Institute of Cardiology, Rio de Janeiro, Brazil; Nutrition and Dietetic Department, Emilia de Jesus Ferreiro, Nutrition Faculty, Fluminense Federal University, Niterói, RJ, Brazil.
出版信息
Microvasc Res. 2020 May;129:103962. doi: 10.1016/j.mvr.2019.103962. Epub 2019 Nov 28.
OBJECTIVE
This study evaluated the acute effect of a high-carbohydrate snack (HCS) on systemic microvascular function of healthy, young volunteers, using laser speckle contrast imaging (LSCI).
METHODS
Cutaneous microvascular blood flow was assessed in the forearm with LSCI coupled to iontophoresis of acetylcholine, using increasing anodal currents, before and after (25 min) the ingestion of a HCS or water (control). Twenty volunteers (10 male) received a single HCS (70 g of carbohydrates) in the fasting state in the morning.
RESULTS
The area under the curve (AUC) of acetylcholine-induced microvascular vasodilation increased from 17,847 ± 4539 to 20,315 ± 7168 arbitrary perfusion units/s (P = 0.03) after ingestion of a HCS, but was unchanged after the ingestion of water (P = 0.22).
CONCLUSION
A single snack consisting on an acute oral load of carbohydrates induced a significant increase of endothelium-dependent microvascular vasodilation in healthy, young subjects.
目的
本研究使用激光散斑对比成像（LSCI）评估了高碳水化合物零食（HCS）对健康年轻志愿者全身微血管功能的急性影响。
方法
通过 LSCI 结合电渗疗法，在前臂评估皮肤微血管血流，使用递增的阳极电流，在摄入 HCS 或水（对照）之前和之后（25 分钟）进行。20 名志愿者（10 名男性）在早上空腹状态下单次摄入 HCS（70g 碳水化合物）。
结果
乙酰胆碱诱导的微血管扩张的曲线下面积（AUC）从摄入 HCS 前的 17847±4539 增加到摄入后的 20315±7168 任意灌注单位/秒（P=0.03），而摄入水后则没有变化（P=0.22）。
结论
单次摄入由急性口服碳水化合物负荷组成的零食可引起健康年轻受试者内皮依赖性微血管扩张的显著增加。
Zotero 插件