i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal.
Expert Opin Drug Deliv. 2020 Jan;17(1):33-48. doi: 10.1080/17425247.2020.1699913. Epub 2019 Dec 3.
: Buccal mucosa has been described as an attractive site for local and systemic drug delivery, owing its accessibility, safety, and excellent blood supply. The absorption of drugs through buccal mucosa has been assessed by and permeability studies, using animal and cell-based models with close resemblance to the human buccal mucosa.: This paper focuses on the current and permeability studies to analyze the absorption of compounds of interest through buccal mucosa, as well as their advantages and limitations in the preclinical studies of the drugs absorption profiles. The techniques for preparation and preservation of the animal buccal tissue are also discussed to evaluate their interference in the integrity and permeability of the tissues.: Overall, the permeability studies have been useful to evaluate the drugs absorption and to clarify the mechanism of transport of drugs across human buccal mucosa, as well as to explain the enhancement of permeability provided by certain dosage forms. Currently, several researchers have demonstrated particular interest in permeability studies, due to their effectiveness in the evaluation of drug absorption and low costs in the acquisition of buccal mucosa samples.
颊黏膜因其易于接近、安全性好和血液供应良好而被描述为局部和全身药物递送的有吸引力的部位。 和 通透性研究评估了药物通过颊黏膜的吸收情况，这些研究使用了与人类颊黏膜非常相似的动物和基于细胞的模型。本文重点介绍了目前的 和 通透性研究，以分析通过颊黏膜吸收感兴趣的化合物，以及它们在药物吸收特征的临床前研究中的优点和局限性。还讨论了制备和保存动物颊组织的技术，以评估它们对组织完整性和通透性的干扰。总的来说，通透性研究有助于评估药物吸收，并阐明药物跨人颊黏膜的转运机制，以及解释某些剂型提供的通透性增强。目前，由于 在评估药物吸收方面的有效性和获取颊黏膜样本的低成本，许多研究人员对 通透性研究表现出特别的兴趣。
