Vilim V, Nerudova J, Frantik E, Holusa R
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
Biomed Biochim Acta. 1988;47(2):205-9.
Single intraperitoneal injection of acrylonitrile, administered prior to the start, at the onset, or during oxygen exposure, respectively, in all cases significantly impaired the survival rate of rats exposed to 98% oxygen. Short periods of lung glutathione depletion by acrylonitrile accelerated the manifestation of O2 toxicity regardless of their timing with respect to the start of oxygen exposure, but in dependence on their intensity and duration. However, the effect of acrylonitrile was probably not solely glutathione-depletion-mediated, since O2 toxicity was enhanced even by acrylonitrile injection, given sufficiently in advance to allow the lung glutathione level to recover before the oxygen exposure started.
分别在开始、刚开始或氧气暴露期间，对大鼠进行单次腹腔注射丙烯腈，在所有情况下，均显著损害了暴露于98%氧气环境中的大鼠的存活率。丙烯腈导致肺内谷胱甘肽短时间耗竭，无论其相对于氧气暴露开始的时间如何，都会加速氧气毒性的表现，但这取决于其强度和持续时间。然而，丙烯腈的作用可能并非仅由谷胱甘肽耗竭介导，因为即使在氧气暴露开始前足够早地注射丙烯腈，以使肺内谷胱甘肽水平在氧气暴露开始前恢复，氧气毒性仍会增强。
