Neveu Gaëlle, Lavazec Catherine
Inserm U1016, CNRS UMR 8104, Université de Paris, Institut Cochin, Paris, France.
Laboratoire d'Excellence GR-Ex, Paris, France.
Front Microbiol. 2019 Nov 8;10:2652. doi: 10.3389/fmicb.2019.02652. eCollection 2019.
sexual parasites, called gametocytes, are the only parasite stages responsible for transmission from humans to mosquitoes. During their maturation, gametocytes remodel the structural and mechanical properties of the membrane of their erythrocyte host. This remodeling is induced by the export of several parasite proteins and a dynamic reorganization of the erythrocyte cytoskeleton. Some of these modifications are specific for sexual stages and play a key role for gametocyte maturation, sequestration in internal organs, subsequent release in the bloodstream and ability to persist in circulation. Here we discuss the mechanisms developed by gametocytes to remodel their host cell and the functional relevance of these modifications.
性寄生虫,即配子体,是唯一负责从人类传播至蚊子的寄生虫阶段。在其成熟过程中,配子体会重塑其红细胞宿主细胞膜的结构和力学特性。这种重塑是由几种寄生虫蛋白的输出以及红细胞细胞骨架的动态重组所诱导的。其中一些修饰是性阶段特有的,对配子体成熟、在内部器官中滞留、随后在血液中释放以及在循环中持续存在的能力起着关键作用。在此,我们讨论配子体为重塑其宿主细胞所形成的机制以及这些修饰的功能相关性。