青少年运动员在深夜进行力竭运动后摄入褪黑素，可减轻次日短期高强度运动期间的肌肉损伤、氧化应激和炎症反应。
Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes.
作者信息
Cheikh Mohamed, Makhlouf Khouloud, Ghattassi Kais, Graja Ahmed, Ferchichi Salyma, Kallel Choumous, Houda Mallek, Souissi Nizar, Hammouda Omar
机构信息
High institute of sport and physical education Ksar-Said, Manouba university, Manouba, Tunisia.
High institute of sport and physical education, Sfax university, Sfax, Tunisia.
出版信息
Chronobiol Int. 2020 Feb;37(2):236-247. doi: 10.1080/07420528.2019.1692348. Epub 2019 Dec 2.
The present study aimed to investigate whether nocturnal melatonin (MEL) ingestion has beneficial effects against exercise-induced oxidative stress and muscle damage in young athletes. Fourteen healthy-trained teenagers performed two-test sessions separated by at least, 1 week. During each session, participants completed the Running-Based Anaerobic Sprint Test (RAST) at 20:00 h. Then, they ingested a single 10-mg tablet of MEL or Placebo (PLA) in a double-blind randomized order at 22:00 h. The following morning (i.e., 07:30 h), participants performed the same test as the previous night. Blood samples were taken before and after exercise. MEL intake increased the peak power (P) ( < .01), mean power (P) ( < .001) and decreased the total time (TT) ( < .001) and the fatigue index (FI) ( < .05). Furthermore, MEL ingestion attenuated the hematologic parameters before and after exercise (White Blood Cells (WBC: < .001 and < .001, respectively); Neutrophiles (NE: < .001 and < .001, respectively); Lymphocytes (LY: < .001 and < .001, respectively)) and the ultra-sensitive C-reactive protein (us-CRP: < .001 and < .001; respectively) compared to PLA. Also, MEL reduced muscle and hepatic damage enzymes before and after exercise (creatine kinase (CK: < .001 and < .001; respectively), lactate dehydrogenase (LDH: < .05 and < .01; respectively), aspartate aminotransferase (ASAT: < .01 and < .001; respectively)), (MDA: < .001 and < .001; respectively) and Homocysteine (Hcy: < .001 and < .001; respectively)) from placebo. Plasma lactate [La] and glucose (GL) remained unchangeable during the two conditions. In summary, acute MEL ingestion after strenuous late-evening exercise attenuated transient leucocytosis and protected against lipid peroxidation and muscle damage induced by strenuous exercise the following morning in healthy male teenage athletes.
本研究旨在调查夜间摄入褪黑素（MEL）是否对年轻运动员运动诱导的氧化应激和肌肉损伤具有有益作用。十四名经过健康训练的青少年进行了两次测试，测试间隔至少1周。在每次测试期间，参与者于20:00进行基于跑步的无氧冲刺测试（RAST）。然后，他们在22:00以双盲随机顺序服用一片10毫克的MEL或安慰剂（PLA）。第二天早上（即07:30），参与者进行与前一晚相同的测试。在运动前后采集血样。摄入MEL增加了峰值功率（P）（P < 0.01）、平均功率（P）（P < 0.001），并减少了总时间（TT）（P < 0.001）和疲劳指数（FI）（P < 0.05）。此外，与PLA相比，摄入MEL减弱了运动前后的血液学参数（白细胞（WBC：分别为P < 0.001和P < 0.001）；中性粒细胞（NE：分别为P < 0.001和P < 0.001）；淋巴细胞（LY：分别为P < 0.001和P < 0.001））以及超敏C反应蛋白（us-CRP：分别为P < 0.001和P < 0.001）。同样，MEL降低了运动前后肌肉和肝脏损伤酶（肌酸激酶（CK：分别为P < 0.001和P < 0.001）、乳酸脱氢酶（LDH：分别为P < 0.05和P < 0.01）、天冬氨酸转氨酶（ASAT：分别为P < 0.01和P < 0.001））、丙二醛（MDA：分别为P < 0.001和P < 0.001）和同型半胱氨酸（Hcy：分别为P < 0.001和P < 0.001）的水平，与安慰剂相比。在两种情况下，血浆乳酸[La]和葡萄糖（GL）保持不变。总之，在深夜剧烈运动后急性摄入MEL可减弱短暂性白细胞增多，并防止健康男性青少年运动员次日早晨因剧烈运动引起的脂质过氧化和肌肉损伤。
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