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前交叉韧带重建中的生物可吸收支架

Bioresorbable Stent in Anterior Cruciate Ligament Reconstruction.

作者信息

Ficek Krzysztof, Rajca Jolanta, Stolarz Mateusz, Stodolak-Zych Ewa, Wieczorek Jarosław, Muzalewska Małgorzata, Wyleżoł Marek, Wróbel Zygmunt, Binkowski Marcin, Błażewicz Stanisław

机构信息

Department of Science, Innovation and Development, Galen-Orthopaedics, 43-150 Bierun, Poland.

Department of Physiotherapy, Academy of Physical Education, 40-065 Katowice, Poland.

出版信息

Polymers (Basel). 2019 Nov 29;11(12):1961. doi: 10.3390/polym11121961.

DOI:10.3390/polym11121961
PMID:31795412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6960761/
Abstract

The exact causes of failure of anterior cruciate ligament (ACL) reconstruction are still unknown. A key to successful ACL reconstruction is the prevention of bone tunnel enlargement (BTE). In this study, a new strategy to improve the outcome of ACL reconstruction was analyzed using a bioresorbable polylactide (PLA) stent as a catalyst for the healing process. The study included 24 sheep with 12 months of age. The animals were randomized to the PLA group (n = 16) and control group (n = 8), subjected to the ACL reconstruction with and without the implantation of the PLA tube, respectively. The sheep were sacrificed 6 or 12 weeks post-procedure, and their knee joints were evaluated by X-ray microcomputed tomography with a 50 μm resolution. While the analysis of tibial and femoral tunnel diameters and volumes demonstrated the presence of BTE in both groups, the enlargement was less evident in the PLA group. Also, the microstructural parameters of the bone adjacent to the tunnels tended to be better in the PLA group. This suggested that the implantation of a bioresorbable PLA tube might facilitate osteointegration of the tendon graft after the ACL reconstruction. The beneficial effects of the stent were likely associated with osteogenic and osteoconductive properties of polylactide.

摘要

前交叉韧带（ACL）重建失败的确切原因仍不清楚。成功进行ACL重建的关键在于预防骨隧道扩大（BTE）。在本研究中，分析了一种新的策略，即使用可生物吸收的聚丙交酯（PLA）支架作为愈合过程的催化剂来改善ACL重建的结果。该研究纳入了24只12月龄的绵羊。将这些动物随机分为PLA组（n = 16）和对照组（n = 8），分别在有或没有植入PLA管的情况下进行ACL重建。术后6周或12周处死绵羊，并通过分辨率为50μm的X射线显微计算机断层扫描对其膝关节进行评估。虽然对胫骨和股骨隧道直径及容积的分析表明两组均存在BTE，但PLA组的扩大不太明显。此外，PLA组中隧道附近骨的微观结构参数往往更好。这表明植入可生物吸收的PLA管可能会促进ACL重建后肌腱移植物的骨整合。支架的有益效果可能与聚丙交酯的成骨和骨传导特性有关。

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