Oliveira Valéria da Costa, Mendes Junior Artur Augusto Velho, Cavalcanti Maíra Cruz de Holanda, Madeira Maria de Fátima, Ferreira Luiz Cláudio, Figueiredo Fabiano Borges, Campos Monique Paiva de, Nadal Niara Vanat, Almosny Nádia Regina Pereira, Menezes Rodrigo Caldas
Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil, 4365, Rio de Janeiro CEP: 21040-360, Brazil.
Instituto Carlos Chagas, Fundação Oswaldo Cruz, Rua Professor Algacyr Munhoz Mader, 3775, Curitiba, Paraná CIC: 81350-010, Brazil.
Vet Parasitol Reg Stud Reports. 2019 Dec;18:100351. doi: 10.1016/j.vprsr.2019.100351. Epub 2019 Nov 13.
This article reports the case of a domestic dog naturally coinfected with the nematode Dioctophyme renale and with the protozoan Leishmania infantum. The dog exhibited no clinical signs but had normocytic hypochromic anemia, hyperproteinemia, hyperglobulinemia, hypoalbuminemia, and hematuria. Necropsy revealed eight D. renale specimens in the abdominal cavity and in right kidney whose parenchyma was atrophied. Histopathological analysis showed glomerular atrophy, fibrosis and a marked diffuse pyogranulomatous inflammatory infiltrate in the right kidney. Moderate multifocal granulomatous peritonitis was observed in the greater omentum. Several Dioctophyme renale eggs were present amidst the inflammatory infiltrate of the right kidney and greater omentum. Leishmania infantum parasites were detected in perirenal adipose tissue of the right kidney, greater omentum, spleen, bone marrow, and popliteal lymph node. The high D. renale load and the severe and uncommon histological alterations associated with the eggs of this parasite may have been influenced by coinfection with L. infantum.
本文报道了一例家犬自然感染肾膨结线虫和婴儿利什曼原虫的病例。该犬无临床症状，但出现正细胞低色素性贫血、高蛋白血症、高球蛋白血症、低白蛋白血症和血尿。尸检发现腹腔和右肾中有8个肾膨结线虫标本，右肾实质萎缩。组织病理学分析显示右肾有肾小球萎缩、纤维化和明显的弥漫性脓性肉芽肿性炎症浸润。在大网膜中观察到中度多灶性肉芽肿性腹膜炎。在右肾和大网膜的炎症浸润中存在数个肾膨结线虫卵。在右肾肾周脂肪组织、大网膜、脾脏、骨髓和腘窝淋巴结中检测到婴儿利什曼原虫寄生虫。肾膨结线虫的高负荷以及与该寄生虫卵相关的严重且罕见的组织学改变可能受到与婴儿利什曼原虫共感染的影响。
