Dorevitch M I, Clemens L E, Webb J B
Department of Rheumatology, St Vincent's Hospital, Melbourne, Australia.
Br J Rheumatol. 1988 Oct;27(5):403-6. doi: 10.1093/rheumatology/27.5.403.
A 34-year-old woman with scleroderma was admitted to hospital with pain and weakness of her left foot. She was subsequently shown to have developed a popliteal artery occlusion associated with progressive lower limb ischaemia. This culminated in below-knee amputation. Marked intimal hyperplasia of the large vessels in the leg was noted histologically. An increasing number of cases of large vessel involvement in scleroderma, a disease that primarily affects the microvasculature, has been reported. Scleroderma should be regarded as a rare cause of large vessel peripheral vascular disease.
一名34岁的硬皮病女性因左脚疼痛和无力入院。随后发现她出现了腘动脉闭塞，并伴有进行性下肢缺血。这最终导致了膝下截肢。组织学检查发现腿部大血管有明显的内膜增生。据报道，硬皮病这种主要影响微血管的疾病，累及大血管的病例越来越多。硬皮病应被视为大血管周围血管疾病的罕见病因。
