Langlais Philip J
Philip J. Langlais, Ph.D., is a professor in the Department of Neurosciences at the University of California San Diego, School of Medicine, in the Neurology Service of the San Diego Veterans Affairs Medical Center, and in the Department of Psychology, San Diego State University, San Diego, California.
Alcohol Health Res World. 1995;19(2):113-121.
Chronic alcohol abuse is associated with several neurological disorders, including Wernicke-Korsakoff syndrome (WKS). Deficiency of thiamine-a vitamin essential for the metabolism and function of brain cells-is thought to be one factor contributing to the cognitive deficits and brain pathology characteristic of WKS. Excessive alcohol consumption may contribute to thiamine deficiency in several ways. Studies in human patients and animal models of WKS are attempting to identify brain structures affected by thiamine deficiency and to correlate them with the cognitive deficits observed in WKS patients.
长期酗酒与多种神经系统疾病有关，包括韦尼克-科尔萨科夫综合征（WKS）。硫胺素（一种对脑细胞代谢和功能至关重要的维生素）缺乏被认为是导致WKS认知缺陷和脑部病变特征的一个因素。过量饮酒可能通过多种方式导致硫胺素缺乏。对WKS人类患者和动物模型的研究正试图确定受硫胺素缺乏影响的脑结构，并将它们与WKS患者中观察到的认知缺陷联系起来。
