一名已知WNT10A基因突变患者的儿童期起病精神病病例报告。
Case Report of Childhood-Onset Psychosis in a Patient with a Known WNT10A Mutation.
作者信息
Kobza Alexandra O, Alenezi Shuliweeh
机构信息
Department of Child and Adolescent Psychiatry, Children's Hospital of Eastern Ontario, Ottawa, Ontario.
Department of Psychiatry, King Saud University, Riyadh, Saudi Arabia.
出版信息
J Can Acad Child Adolesc Psychiatry. 2019 Nov;28(3):147-150. Epub 2019 Nov 1.
OBJECTIVE
To report on a patient with childhood-onset psychosis at age 12 with a known WNT10A mutation.
METHODS
Case report.
RESULTS
The patient is a 12-year-old male who presented with an acute onset of psychosis in the context of a known WNT10A mutation.
CONCLUSION
WNT genes have only been previously linked to schizophrenia on a theoretical basis. To our knowledge, this is the first case report of an association between a childhood-onset psychosis and a WNT10A mutation. We conclude that there is a possibility that WNT10A may be one of the many genes contributing to the development of childhood-onset schizophrenia.
目的
报告一名12岁患有已知WNT10A突变的儿童期起病精神病患者。
方法
病例报告。
结果
该患者为一名12岁男性，在已知WNT10A突变的情况下急性起病精神病。
结论
WNT基因此前仅在理论基础上与精神分裂症相关联。据我们所知，这是第一例关于儿童期起病精神病与WNT10A突变之间关联的病例报告。我们得出结论，WNT10A有可能是导致儿童期起病精神分裂症发生的众多基因之一。
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