Romani L, Bianchi R, Nardelli B, Circolo A, Andrielli M
Boll Soc Ital Biol Sper. 1979 Oct 15;55(19):1981-7.
Specific cytotoxic T cells were obtained by coculturing "in vitro" normal spleen cells with inactivated histocompatible DTIC-altered lymphoma cells. The "in vivo" antitumor activity of such sensitized lymphocytes was evaluated by injecting a mixture of lymphocytes + tumor into the brains of lethally irradiated syngenic mice. The results indicated that such lymphocytes demonstrate antitumor activity against the same tumor but not against unrelated tumors.
通过将正常脾细胞与经组织相容性改变的灭活达卡巴嗪（DTIC）处理的淋巴瘤细胞“体外”共培养，获得了特异性细胞毒性T细胞。通过将淋巴细胞+肿瘤的混合物注射到致死剂量照射的同基因小鼠脑中，评估了这种致敏淋巴细胞的“体内”抗肿瘤活性。结果表明，此类淋巴细胞对同一肿瘤具有抗肿瘤活性，但对无关肿瘤则无活性。
