Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Critical Care Medicine, Sir Run Run Shaw Hospital Xiasha Campus, Zhejiang University School of Medicine, Hangzhou, China.
Int J Clin Pract. 2020 Mar;74(3):e13458. doi: 10.1111/ijcp.13458. Epub 2019 Dec 14.
Hypertriglycaeridemia has been positively associated with the risk of acute pancreatitis, but whether increased triglyceride (TG) levels are related to the severity of pancreatitis remains unclear. The aim of this study was to assess the relationship between hyperlipidaemia and disease severity of hypertriglycaeridemic pancreatitis.
From 2016 to 2018, patients with hypertriglyceridaemic pancreatitis presented within 24 hours from symptom onset were retrospectively enrolled. The severity was classified by the Atlanta classification 2012. The demographic and clinical characteristics of patients were compared with respect to severity stratification and different TG categories, respectively. The relationships of admission TG levels and disease severity were assessed with Spearman's rank correlation test and Linear-by-Linear Association test.
Among 256 patients included, 125 (48.8%) were diagnosed with mild (MAP), 76 (29.7%) with moderate (MSAP) and 55 (21.5%) with severe acute pancreatitis (SAP). The mean TGs (standard derivation) on admission in patients with MAP, MSAP and SAP were 21.6 (15.2) mmol/L (1913 [1346] mg/dL), 34.6 (22.6) mmol/L (3065 [2002] mg/dL) and 41.5 (32.5) mmol/L (3676 [2879] mg/dL), respectively (P < .001). Patients were then categorised based on their TG levels. TG categories had a strong positive correlation with the disease severity (Rho = 0.34, P < .001). Positive trend for the association across increasing TG categories and SAP was observed (P < .001).
Elevated serum TG levels at the time of admission seem to correlate positively with the severity of hypertriglyceridaemia-induced acute pancreatitis.
高甘油三酯血症与急性胰腺炎的风险呈正相关，但甘油三酯（TG）水平升高是否与胰腺炎的严重程度有关尚不清楚。本研究旨在评估高脂血症与高甘油三酯血症性胰腺炎严重程度的关系。
回顾性纳入 2016 年至 2018 年发病 24 小时内就诊的高甘油三酯血症性胰腺炎患者。根据 2012 年亚特兰大分类标准对严重程度进行分类。分别比较不同严重程度分层和不同 TG 分类患者的人口统计学和临床特征。采用 Spearman 秩相关检验和线性逐行关联检验评估入院 TG 水平与疾病严重程度的关系。
共纳入 256 例患者，其中 125 例（48.8%）为轻症急性胰腺炎（MAP），76 例（29.7%）为中度重症急性胰腺炎（MSAP），55 例（21.5%）为重症急性胰腺炎（SAP）。MAP、MSAP 和 SAP 患者入院时的平均 TG（标准差）分别为 21.6（15.2）mmol/L（1913[1346]mg/dL）、34.6（22.6）mmol/L（3005[2002]mg/dL）和 41.5（32.5）mmol/L（3676[2879]mg/dL），差异具有统计学意义（P<0.001）。随后，根据患者的 TG 水平进行分组。TG 分类与疾病严重程度呈强正相关（Rho=0.34，P<0.001）。随着 TG 分类的增加，SAP 的关联呈上升趋势（P<0.001）。
入院时血清 TG 水平升高似乎与高甘油三酯血症性胰腺炎的严重程度呈正相关。
