Lu Zhihua, Chen Xiangping, Ge Huiqing, Li Man, Feng Binbin, Wang Donghai, Guo Feng
Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Respiratory Care, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Gastroenterol Res Pract. 2022 Mar 16;2022:8333794. doi: 10.1155/2022/8333794. eCollection 2022.
The neutrophil-lymphocyte ratio (NLR) has been proposed as a surrogate marker of inflammation with prognostic value in various diseases. Our objective was to investigate the predictive value of the NLR as an indicator of persistent organ failure (POF) in patients with hypertriglyceridemic pancreatitis (HTGP).
We retrospectively reviewed the data from patients with HTGP between 2016 and 2019. The NLR was obtained at admission. The diagnostic performance of the NLR for POF was evaluated by the area under the receiver operator characteristics curve (AUROC). Multivariate logistic regression determined whether elevated NLR was independently associated with POF.
Of the 446 patients enrolled, 89 (20.0%) developed POF. Patients with POF showed a significantly higher NLR than those without POF ( < 0.001). A positive trend for the association across increasing NLR quartiles and the incidence of POF was observed ( < 0.001). The AUROC of NLR to predict POF was 0.673 (95% confidence interval, 0.627-0.716). With a cut-off of NLR > 6.56, the sensitivity and specificity were 73.0% and 55.7%, respectively. Multivariate analysis suggested that high NLR (>6.56) was independently associated with POF (odds ratio, 2.580; 95% confidence interval, 1.439-4.626; = 0.001). Patients with a high NLR (>6.56) had a worse overall clinical course in HTGP.
Elevated NLR was significantly associated with an increased risk of developing POF and could be an early independent predictor of POF in patients with HTGP.
中性粒细胞与淋巴细胞比值（NLR）已被提议作为炎症的替代标志物，在多种疾病中具有预后价值。我们的目的是研究NLR作为高甘油三酯性胰腺炎（HTGP）患者持续性器官衰竭（POF）指标的预测价值。
我们回顾性分析了2016年至2019年间HTGP患者的数据。入院时测定NLR。通过受试者操作特征曲线下面积（AUROC）评估NLR对POF的诊断性能。多因素逻辑回归确定NLR升高是否与POF独立相关。
在纳入的446例患者中，89例（20.0%）发生POF。发生POF的患者NLR显著高于未发生POF的患者（<0.001）。观察到NLR四分位数增加与POF发生率之间呈正相关趋势（<0.001）。NLR预测POF的AUROC为0.673（95%置信区间，0.627 - 0.716）。NLR>6.56时，敏感性和特异性分别为73.0%和55.7%。多因素分析表明，高NLR（>6.56）与POF独立相关（比值比，2.580；95%置信区间，1.439 - 4.626；=0.001）。NLR高（>6.56）的患者在HTGP中的总体临床病程更差。
NLR升高与发生POF的风险增加显著相关，可能是HTGP患者POF的早期独立预测指标。
