使用未成熟血小板分数预测登革热感染患者血小板恢复时间。
The use of immature platelet fraction to predict time to platelet recovery in patients with dengue infection.
机构信息
Departments of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Departments of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Paediatr Int Child Health. 2020 May;40(2):124-128. doi: 10.1080/20469047.2019.1697574. Epub 2019 Dec 6.
: In dengue infection, knowing time to platelet recovery is essential for optimal management.: To determine a predictor for platelet recovery in patients with dengue infection.: Platelet count and immature platelet fraction (IPF) from daily blood samples of patients with dengue infection during hospitalisation and 1-4 weeks after discharge were retrospectively analysed. The levels of patients' IPF were compared with normal controls recruited from healthy children with normal platelet counts.: A total of 244 EDTA blood samples were collected daily from 64 patients (45 males) with dengue infection (36 dengue fever, 28 dengue haemorrhagic fever) during hospitalisation and after discharge from the hospital. They did not receive any platelet concentrate transfusion. The median IPF among normal children was 3.6% with a 95 percentile of 9.9%. In dengue patients, an IPF of ≥10.0% after defervescence was associated with a subsequent platelet count of ≥60 × 10/L within 72 hours.: In patients with dengue infection, IPF ≥10.0% after defervescence is a predictor of subsequent platelet recovery to a haemostatic level ≥60 × 10/L within 72 hours.
在登革热感染中，了解血小板恢复的时间对于最佳管理至关重要。
目的
确定登革热感染患者血小板恢复的预测因子。
方法
回顾性分析了住院期间和出院后 1-4 周内登革热感染患者的每日血液样本中的血小板计数和未成熟血小板分数（IPF）。将患者的 IPF 水平与从血小板计数正常的健康儿童中招募的正常对照进行比较。
结果
共收集了 64 例（男性 45 例）登革热感染（登革热 36 例，登革出血热 28 例）患者的 244 份 EDTA 血样，每天一份，这些患者在住院期间和出院后均未接受任何血小板浓缩物输注。正常儿童的中位 IPF 为 3.6%，95%可信区间为 9.9%。在登革热患者中，退热后 IPF≥10.0%与 72 小时内血小板计数≥60×10/L 的后续血小板恢复相关。
结论
在登革热感染患者中，退热后 IPF≥10.0%是血小板恢复至止血水平≥60×10/L 的预测因子。
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