Luger A
Aktuelle Gerontol. 1978 Nov;8(11):569-78.
The term "precancerous" needs a new definition since it includes still malignant diseases like Morbus Paget of the nipple, Morbus Bowen and Erythroplasie Queyrat. The degree of malignancy of these disorders is analyzed. Precancerous conditions in the sense of benignant disorders which necessarily develop into malignant tumors are Melanosis circumscripta praeblastomatosa Dubreuilh and actinic keratoses. Potential precanceroses may be X-ray-atrophy, Leukoplakia and oral papillomatosis. Some actinic, chemic and cytostatic cancerogens are mentioned. Reference is made to the diagnosis, differential diagnosis, prognosis and treatment of precancerous skin lesions. The problem of potential malignancy of nevi is considered in detail. Prevention of cancer needs regular careful clinical control of skin and mucous membranes at least after the 50th year of life.
“癌前”一词需要一个新的定义,因为它包括仍属恶性疾病的乳头佩吉特病、鲍恩病和凯拉特增殖性红斑。对这些病症的恶性程度进行了分析。从必然会发展为恶性肿瘤的良性病症意义上来说,癌前状况有杜布雷伊局限性成黑素细胞瘤前期和光化性角化病。潜在的癌前病变可能有X线萎缩、白斑病和口腔乳头瘤病。提到了一些光化性、化学性和细胞抑制性致癌物。文中还提及了癌前皮肤病变的诊断、鉴别诊断、预后及治疗。详细讨论了痣的潜在恶性问题。癌症预防至少在50岁以后需要对皮肤和黏膜进行定期仔细的临床检查。