胰岛淀粉样多肽：人类基因的鉴定与染色体定位

Islet amyloid polypeptide: identification and chromosomal localization of the human gene.

作者信息

Mosselman S, Höppener J W, Zandberg J, van Mansfeld A D, Geurts van Kessel A H, Lips C J, Jansz H S

机构信息

Institute of Molecular Biology, University of Utrecht, The Netherlands.

出版信息

FEBS Lett. 1988 Nov 7;239(2):227-32. doi: 10.1016/0014-5793(88)80922-0.

DOI:10.1016/0014-5793(88)80922-0

PMID:3181427

Abstract

Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.

摘要

胰岛或胰岛素瘤淀粉样多肽（IAPP）是一种从胰腺淀粉样物质中分离出的由37个氨基酸组成的多肽。在此，我们描述了编码IAPP的人类基因的分离及部分特征。DNA序列预测IAPP是从一个更大的前体蛋白中切割出来的，并且其羧基末端可能被酰胺化。预测的正常存在的IAPP与从胰腺淀粉样物质中分离出的已报道多肽相同，只是羧基末端被酰胺化。1.6 kb和2.1 kb的IAPP特异性聚腺苷酸化RNA存在于人类胰岛素瘤RNA中。人类IAPP基因位于12号染色体上。