The Department of Surgery and Cancer, Imperial College London, Imperial College London at St Mary's Hospital Campus, 10th Floor, Queen Elizabeth the Queen Mother (QEQM) Building, Praed Street, London, W2 1NY, UK.
Metab Brain Dis. 2013 Sep;28(3):341-53. doi: 10.1007/s11011-013-9412-4. Epub 2013 May 8.
Neurodegenerative diseases are amongst the leading causes of worldwide disability, morbidity and decreased quality of life. They are increasingly associated with the concomitant worldwide epidemic of obesity. Although the prevalence of both AD and PD continue to rise, the available treatment strategies to combat these conditions remain ineffective against an increase in global neurodegenerative risk factors. There is now epidemiological and mechanistic evidence associating obesity and its related disorders of impaired glucose homeostasis, type 2 diabetes mellitus and metabolic syndrome with both AD and PD. Here we describe the clinical and molecular relationship between obesity and neurodegenerative disease. Secondly we outline the protective role of weight loss, metabolic and caloric modifying interventions in the context of AD and PD. We conclude that the application of caloric restriction through dietary changes, bariatric (metabolic) surgery and gut hormone therapy may offer novel therapeutic strategies against neurodegenerative disorders. Investigating the protective mechanisms of weight loss, metabolic and caloric modifying interventions can increase our understanding of these major public health diseases and their management.
神经退行性疾病是全球残疾、发病率和生活质量下降的主要原因之一。它们与肥胖的全球流行密切相关。尽管 AD 和 PD 的患病率仍在持续上升，但现有的治疗策略在对抗全球神经退行性危险因素方面仍然无效。目前有流行病学和机制学证据表明，肥胖及其相关的葡萄糖稳态受损、2 型糖尿病和代谢综合征与 AD 和 PD 有关。在这里，我们描述了肥胖症和神经退行性疾病之间的临床和分子关系。其次，我们概述了减肥、代谢和热量调节干预在 AD 和 PD 中的保护作用。我们得出结论，通过饮食改变、减肥（代谢）手术和肠道激素治疗来应用热量限制可能为神经退行性疾病提供新的治疗策略。研究减肥、代谢和热量调节干预的保护机制可以增加我们对这些主要公共卫生疾病及其管理的理解。
