Paton D M, Webster D R
Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand.
Int J Clin Pharmacol Res. 1988;8(4):227-9.
In a randomized cross-over study, eight healthy volunteers received single 200 mg doses of metronidazole tablets (as either the May and Baker or Servipharm preparation) after an overnight fast. The bioavailability of these two preparations did not differ significantly as judged from the peak plasma concentration, time to peak plasma concentration and area under the plasma concentration-time curve. Metronidazole was found to have a plasma clearance of 1.05 +/- 0.14 (s.d.) and 0.98 +/- 0.17 ml min-1 kg-1, a plasma terminal half-life of elimination of 9.15 +/- 1.01 and 10.35 +/- 1.59 h, and an apparent volume of distribution of 0.83 +/- 0.06 l kg-1 (the values obtained with the May and Baker preparation being shown before the Servipharm preparation in each case).
在一项随机交叉研究中，8名健康志愿者在禁食过夜后单次服用200毫克甲硝唑片（May and Baker或Servipharm制剂）。根据血浆峰浓度、达峰时间和血浆浓度-时间曲线下面积判断，这两种制剂的生物利用度无显著差异。甲硝唑的血浆清除率分别为1.05±0.14（标准差）和0.98±0.17毫升·分钟⁻¹·千克⁻¹，血浆消除终末半衰期分别为9.15±1.01和10.35±1.59小时，表观分布容积为0.83±0.06升·千克⁻¹（每种情况下May and Baker制剂的数据在前，Servipharm制剂的数据在后）。
