Lepore A M, Bonardi G, Maggi G C
Pierrel S.p.A., Research & Development, Milan, Italy.
Int J Clin Pharmacol Res. 1988;8(4):253-7.
Oral absorption of flurithromycin, a new fluorinated macrolide, has been evaluated on eight healthy volunteers on fasting and after a standard meal. Serum levels from 0 to 8 hours, peak serum concentrations, times to peak and areas under the curves were compared using a balanced sequence cross-over design. The highest mean concentration was reached after 3 h from administration on fasting (1.36 +/- 0.31 mcg/ml) and after 1 h following a meal (1.36 +/- 0.30 mcg/ml). All the pharmacokinetic parameters considered showed no statistical change. Therefore a meal does not reduce or delay the absorption of flurithromycin, while in the presence of food other macrolides may behave differently. Moreover the tolerability to the drug was good, lacking any report of side-effects, either on fasting or after the food.
已在8名健康志愿者身上评估了新型氟代大环内酯类药物氟红霉素在空腹和进标准餐后的口服吸收情况。采用平衡序列交叉设计比较了0至8小时的血清水平、血清峰值浓度、达峰时间和曲线下面积。空腹给药后3小时达到最高平均浓度（1.36±0.31微克/毫升），餐后1小时达到最高平均浓度（1.36±0.30微克/毫升）。所有考虑的药代动力学参数均无统计学变化。因此，进餐不会降低或延迟氟红霉素的吸收，而在有食物存在的情况下，其他大环内酯类药物的表现可能不同。此外，该药物的耐受性良好，无论是空腹还是进食后均无任何副作用报告。
