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通透性对分叉狭窄动脉中混合纳米流体血流的显著作用:药物输送应用。

A significant role of permeability on blood flow for hybrid nanofluid through bifurcated stenosed artery: Drug delivery application.

机构信息

Department of Mathematics, Air University, PAF Complex E-9, Islamabad, 44000, Pakistan.

Department of Mathematics, Air University, PAF Complex E-9, Islamabad, 44000, Pakistan.

出版信息

Comput Methods Programs Biomed. 2020 Apr;187:105248. doi: 10.1016/j.cmpb.2019.105248. Epub 2019 Dec 2.

Abstract

OBJECTIVE

The prime objective of concerned article is to discuss the permeability impacts on blood flow by considering hybrid nanofluid through bifurcated stenosed artery.

DESIGN/APPROACH: The human body circulatory framework involves the arrangement of veins that fuse the bifurcation on parent, at apex and on regions of daughter artery with nanoparticles is viewed. Blood streaming is recognized as Newtonian along vessel segment. The walls of the stenosed bifurcated artery is considered to be permeable as well as compliant. Copper and its oxide as used as drug to minimize the stress and the lesions of the atherosclerotic artery.

FINDINGS

The theoretical investigation is carried out by invoking the experimental values of hybrid nanoparticles into the structured equations. Moreover, impacts of hemodynamics are also make sense of to inspect the progression of blood for atherosclerotic vein. Daughter and parent artery comparison is described through parabolic graph of velocity. Graphical illustration is utilized to present the theoretical results of this drug delivery model. Metallic nanoparticles justify their use in drug delivery.

CONCLUSIONS

The flow of blood is viewed as not quite the same as pressure between segments of atherosclerotic and non-atherosclerotic course. Bifurcation angle minimize the stress for daughter artery whereas trend is opposite for parent daughter. The change in compliant wall parameter reduces the circulating bolus size for parent daughter whereas for daughter artery the change in bolus shape is observed.

摘要

目的

相关文章的主要目的是讨论通过考虑分叉狭窄动脉中的混合纳米流体对血流的渗透性影响。

设计/方法:人体循环系统包括静脉的排列,这些静脉将分叉处的母动脉、顶点和子动脉的区域融合在一起,并考虑到纳米粒子。在血管段中,血液被认为是牛顿流体。狭窄分叉动脉的壁被认为是可渗透和顺应的。铜及其氧化物被用作药物来最小化动脉粥样硬化动脉的应力和损伤。

发现

通过将混合纳米粒子的实验值引入结构方程,进行了理论研究。此外,还考虑了血液动力学的影响,以检查粥样硬化静脉中的血液进展。通过速度的抛物线图描述了子和母动脉的比较。利用图形说明来呈现这种药物输送模型的理论结果。金属纳米粒子证明了它们在药物输送中的应用。

结论

血液的流动与动脉粥样硬化和非动脉粥样硬化部位之间的压力不同。分叉角最小化了对子动脉的应力,而对于母-子动脉,趋势则相反。顺应性壁参数的变化减少了母-子动脉的循环血球大小,而对于子动脉,则观察到血球形状的变化。

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