表现为溃疡性脂膜炎的局限性溃疡性结节性淀粉样变性，一种不寻常的临床表现：病例报告

Localized ulcerative nodular amyloidosis presenting as ulcerative panniculitis, an unusual clinical manifestation: A case report.

作者信息

Fernandes Carolina, Éthier Vincent, Marouan Sofia, Chababi-Atallah Myrna, Veilleux Mylène

机构信息

University of Sherbrooke, Sherbrooke, QC, Canada.

出版信息

SAGE Open Med Case Rep. 2019 Nov 29;7:2050313X19890755. doi: 10.1177/2050313X19890755. eCollection 2019.

DOI:10.1177/2050313X19890755

PMID:31827797

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6886270/

Abstract

INTRODUCTION AND OBJECTIVES

The main objective of this article is to present and discuss a case of localized ulcerative nodular amyloidosis with deep involvement clinically manifesting as ulcerative panniculitis and discuss its impact on the choice of treatment.

METHODS AND RESULTS

We present a 73-year-old woman with a history of painful ulcerated nodules on the inferior limbs. Microscopy confirmed amyloid deposits deep in the dermis and subcutaneous fat. No systemic involvement was found. Considering that skin-directed treatments often are not able to reach subcutaneous fat or were contraindicated because of the ulcers, she was successfully treated with cyclophosphamide and prednisone.

CONCLUSION

Localized ulcerative nodular amyloidosis with deep involvement is a rare clinical presentation that can present as ulcerative panniculitis. Such a clinical manifestation might be misleading. Systemic treatment might be necessary to control symptoms when conventional skin-directed therapies are contraindicated.

摘要