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头皮原发性局限性皮肤结节性淀粉样变经切除成功治愈。

Primary Localized Cutaneous Nodular Amyloidosis on Scalp Successfully Treated with Excision.

作者信息

Kwon Il Joo, Yoo Dae San, Roh Mi Ryung

机构信息

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Ann Dermatol. 2023 May;35(Suppl 1):S30-S33. doi: 10.5021/ad.20.137.

Abstract

Primary localized cutaneous nodular amyloidosis (PLCNA) is the rarest form of cutaneous amyloidosis, characterized by nodular deposits of light chain amyloids in the dermis and subcutaneous tissue, without apparent systemic involvement. One or several nodules are preferably located on the extremities, trunk, or face. The most useful stain for detecting amyloid fibrils is Congo red, which, when combined with polarized light, makes amyloid proteins appear apple-green under a microscope. Immunohistochemical staining can help identify the exact type of amyloid proteins. Although the exact etiology of PLCNA is unclear, removal of nodules by shaving or surgical excision has shown good results. To the best of our knowledge, only seven cases of PLCNA have yet been reported in the Korean literature. In three of these cases, the patients had lesions on the scalp. Herein, we present a case of a 34-year-old male with PLCNA on the scalp with all the results of immunohistochemical evaluation.

摘要

原发性局限性皮肤结节性淀粉样变(PLCNA)是皮肤淀粉样变最罕见的一种形式,其特征是真皮和皮下组织中有轻链淀粉样蛋白的结节性沉积,无明显的全身受累。一个或多个结节最好位于四肢、躯干或面部。检测淀粉样纤维最有用的染色方法是刚果红,当与偏振光结合时,淀粉样蛋白在显微镜下呈现苹果绿色。免疫组织化学染色有助于确定淀粉样蛋白的确切类型。虽然PLCNA的确切病因尚不清楚,但通过刮除或手术切除结节已显示出良好的效果。据我们所知,韩国文献中仅报道了7例PLCNA。在其中3例中,患者头皮有病变。在此,我们报告一例34岁男性头皮PLCNA病例,并给出免疫组织化学评估的所有结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be06/10608395/60bcd874845c/ad-35-S30-g001.jpg

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