温泉关之战：300名斯巴达人（自然杀伤细胞加奥滨尤妥珠单抗）对阵薛西斯军队的不死战士（慢性淋巴细胞白血病细胞）。

Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes' army.

作者信息

García-Muñoz Ricardo, Nájera María-Josefa, Feliu Jesús, Antón-Remírez Judith, Ramalle-Gómara Enrique, Marín-Gorricho Raquel, Peralta Raisa, Gutiérrez-Gamarra Elena, Nuñez-Rodriguez Jessica, Zafra-Morales Ricardo, Aguinaga Lorea, Nebot-Villacampa María-Jose, Hernandez-Pérez Prisma-Monserrat, Farfán-Quiroga Giovanna, Panizo Carlos, Domínguez-Garrido Elena

机构信息

Department of Hematology, San Pedro Hospital, 26006 Logroño, La Rioja, Spain.

Department of Physical Medicine & Rehabilitation, Navarra Hospital Complex, Pamplona, Spain.

出版信息

Future Sci OA. 2019 Nov 26;5(10):FSO425. doi: 10.2144/fsoa-2019-0064.

AIM

To analyze the effects of subcutaneous or intravenous rituximab + lymphokine-activated killer cells, obinutuzumab or ibrutinib on natural killer (NK) cell levels in chronic lymphocytic leukemia and follicular lymphoma patients.

PATIENTS & METHODS: The distribution of peripheral blood NK cells of 31 patients was analyzed by flow cytometry.

RESULTS

We detected a decrease of NK cells in peripheral blood below normal range after obinutuzumab treatment. During maintenance treatment with subcutaneous rituximab, an NK cell reduction was less pronounced than after intravenous rituximab treatment, despite lymphokine-activated killer cell infusions.