Jacobson J J, Schweitzer S, DePorter D J, Lee J J
Department of Oral Diagnosis, Oral Medicine, Oral Pathology, UCLA School of Dentistry.
J Dent Educ. 1988 Nov;52(11):599-604.
A computer simulation model was created to assess the risks and effects of no prophylaxis, oral penicillin, and oral cephalexin regimens for dental patients at risk for late prosthetic joint infection (LPJI). Given the assumptions made, this analysis suggests that there is a very small risk of LPJI (29-68 cases per 10(6) dental visits), which is outweighed by a greater risk of death from a fatal antibiotic reaction. Thus, routine predental antibiotic prophylaxis for all dental patients with prosthetic joints may lead to higher mortality. However, clinical experience suggests that antibiotic prophylaxis may be appropriate in "high risk" patients.
创建了一个计算机模拟模型，以评估对于有晚期人工关节感染（LPJI）风险的牙科患者，不进行预防、口服青霉素和口服头孢氨苄治疗方案的风险和效果。基于所做的假设，该分析表明LPJI的风险非常小（每10⁶次牙科就诊有29 - 68例），但因致命抗生素反应导致的死亡风险更高。因此，对所有有假体关节的牙科患者进行常规牙科前抗生素预防可能会导致更高的死亡率。然而，临床经验表明，抗生素预防在“高危”患者中可能是合适的。
