史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的结肠受累：胃肠道出血的罕见原因
Colonic Involvement of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Rare Cause of Gastrointestinal Bleeding.
作者信息
Claytor Jennifer D, Herfarth Hans H, Weaver Kimberly N
机构信息
Department of Internal Medicine, University of California at San Francisco, San Francisco, CA.
Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
出版信息
ACG Case Rep J. 2019 Oct 17;6(10):e00242. doi: 10.14309/crj.0000000000000242. eCollection 2019 Oct.
Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represents a spectrum of rare but severe mucocutaneous drug reactions. Gastrointestinal involvement of SJS/TEN is associated with high morbidity and mortality and often presents 2-3 weeks after the initial appearance of skin lesions. There are no evidence-based treatment algorithms for the management of SJS/TEN. We report a case of life-threatening gastrointestinal bleeding from colonic involvement of SJS/TEN and discuss potential therapeutic options.
史蒂文斯-约翰逊综合征（SJS）/中毒性表皮坏死松解症（TEN）是一系列罕见但严重的皮肤黏膜药物不良反应。SJS/TEN累及胃肠道时，发病率和死亡率较高，且常在皮肤病变初现后2 - 3周出现。目前尚无基于循证医学的SJS/TEN治疗方案。我们报告1例因SJS/TEN累及结肠导致危及生命的胃肠道出血病例，并探讨潜在的治疗选择。
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