Section of Periodontics, Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome, Rome, Italy.
Division of Periodontology, Department of Dentistry, Albanian University, Tirana, Albania.
J Periodontol. 2020 Jul;91(7):938-946. doi: 10.1002/JPER.19-0443. Epub 2019 Dec 29.
Individuals with altered passive eruption (APE) are assumed to be more susceptible to periodontal diseases. To date, this hypothesis has not been sufficiently supported by scientific evidence. The aim of this study, using an experimental gingivitis model, was to examine the development and resolution of gingival inflammation in patients with APE when compared to patients with normal gingival anatomy.
A localized experimental gingivitis was induced in 9 patients with APE (test group) and 9 patients without APE (control group) in the maxillary right quadrant. After 21 days, patients were instructed to resume proper home oral hygiene procedures. At baseline (day 0) and at days 7, 14, 21, 28, 35, and 42, plaque index (PlI), gingival index (GI), and gingival crevicular fluid volume (GCF) were evaluated for teeth 6 (canine), 7 (lateral incisor) and 8 (central incisor) of test and control groups.
During the experimental gingivitis phase (days 0 to 21), the rate of change in gingival inflammation (GI) was dramatically different between the APE test group and the control group. On day 21, at the time of maximum plaque accumulation, the GI of the APE test group was a 109% greater than the GI of the test group (P ≤ 0.001) despite similar plaque levels (P = 0.436). During the resolution of inflammation phase (days 22 to 42), the APE test group continued to exhibit statistically higher GI scores than the control group (P = 0.029).
In the presence of similar amounts of plaque deposits and plaque accumulation rates, APE patients exhibited differences in the development and resolution of plaque-induced gingival inflammation when compared to controls.
患有被动萌出异常（APE）的个体被认为更容易患牙周病。迄今为止，这一假设尚未得到充分的科学证据支持。本研究旨在通过实验性龈炎模型，比较 APE 患者和正常牙龈解剖结构患者的牙龈炎症发展和消退情况，以验证这一假说。
在 9 名 APE 患者（试验组）和 9 名无 APE 患者（对照组）的上颌右侧象限内诱导局部实验性龈炎。21 天后，嘱患者恢复适当的家庭口腔卫生措施。在基线（第 0 天）和第 7、14、21、28、35 和 42 天，评估试验组和对照组 6（尖牙）、7（侧切牙）和 8（中切牙）牙齿的菌斑指数（PlI）、牙龈指数（GI）和龈沟液量（GCF）。
在实验性龈炎阶段（第 0 至 21 天），APE 试验组和对照组之间牙龈炎症（GI）的变化率差异很大。第 21 天，在菌斑积累最多的时间点，APE 试验组的 GI 比试验组高 109%（P≤0.001），尽管菌斑水平相似（P=0.436）。在炎症消退阶段（第 22 至 42 天），APE 试验组的 GI 评分继续高于对照组（P=0.029）。
在菌斑沉积量和菌斑积累率相似的情况下，与对照组相比，APE 患者在菌斑诱导的牙龈炎症的发展和消退方面表现出差异。
