同型 Co(ii) 顺磁 CEST 试剂作为 pH 响应 MRI 探针。
Isomeric Co(ii) paraCEST agents as pH responsive MRI probes.
机构信息
Department of Chemistry, Natural Sciences Complex, University at Buffalo, the State University of New York, Amherst, NY 14260, USA.
出版信息
Dalton Trans. 2020 Jan 2;49(2):279-284. doi: 10.1039/c9dt04558a.
A newly discovered isomer of Co(ii) (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane = CCRM) produces four highly paramagnetically shifted chemical exchange saturation transfer (CEST) peaks. The 1,8-pendants of the complex are bound in a trans-arrangement to produce a Co(ii) complex of increased kinetic inertness. The isomers have a stabilized Co(ii) center (E1/2 of 540 to 550 mV versus SHE). Both the 1,8 and the 1,4-isomer are excellent pH probes in solution and in tissue homogenate by virtue of their highly paramagnetically shifted amide protons. These isomers produce both a ratiometric pH readout as well as amide proton exchange rate constants that correlate to pH.
一种新发现的 Co(ii) 异构体（1,4,8,11-四（氨甲酰甲基）-1,4,8,11-四氮杂环十四烷=CCRM）产生了四个高顺磁位移的化学交换饱和转移（CEST）峰。该配合物的 1,8-臂以反式排列结合，产生了具有更高动力学惰性的 Co(ii)配合物。该异构体具有稳定的 Co(ii)中心（相对于 SHE 的 E1/2 为 540 至 550 mV）。由于其高顺磁位移的酰胺质子，1,8-异构体和 1,4-异构体在溶液中和组织匀浆中都是出色的 pH 探针。这些异构体产生了一种比率型 pH 读数以及与 pH 相关的酰胺质子交换速率常数。
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