CoCEST：钴（II）酰胺附加以实现的 paraCEST MRI 对比剂。
CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents.
机构信息
Department of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.
出版信息
Chem Commun (Camb). 2013 Nov 4;49(85):10025-7. doi: 10.1039/c3cc45000g.
Abstract
The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.
摘要
首次报道了稳定的 Co(II) 顺磁 CEST MRI 对比剂的实例。配合物上的酰胺 NH 质子产生 CEST 峰，其从体相水共振峰位移高达 112 ppm。一种配合物具有多个 CEST 峰，这可能对 pH 的比率映射有用。
相似文献
1
CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents.CoCEST：钴（II）酰胺附加以实现的 paraCEST MRI 对比剂。
Chem Commun (Camb). 2013 Nov 4;49(85):10025-7. doi: 10.1039/c3cc45000g.
2
Co(II) Macrocyclic Complexes Appended with Fluorophores as paraCEST and cellCEST Agents.带有荧光团的 Co(II) 大环配合物作为 paraCEST 和细胞 CEST 试剂。
Inorg Chem. 2020 Nov 16;59(22):16531-16544. doi: 10.1021/acs.inorgchem.0c02470. Epub 2020 Nov 2.
3
Seven-coordinate Co(II), Fe(II) and six-coordinate Ni(II) amide-appended macrocyclic complexes as ParaCEST agents in biological media.七配位钴（II）、铁（II）和六配位镍（II）酰胺基大环配合物作为生物介质中的顺磁化学交换饱和转移（ParaCEST）试剂。
Inorg Chem. 2014 Aug 18;53(16):8311-21. doi: 10.1021/ic5006083. Epub 2014 May 13.
4
Six, Seven or Eight Coordinate Fe(II) , Co(II) or Ni(II) Complexes of Amide-Appended Tetraazamacrocycles for ParaCEST Thermometry.用于顺磁化学交换饱和转移（ParaCEST）温度测量的酰胺连接四氮杂大环的六、七或八配位铁（II）、钴（II）或镍（II）配合物
Chemistry. 2015 Dec 7;21(50):18290-300. doi: 10.1002/chem.201503125. Epub 2015 Oct 23.
5
Isomeric Co(ii) paraCEST agents as pH responsive MRI probes.同型 Co(ii) 顺磁 CEST 试剂作为 pH 响应 MRI 探针。
Dalton Trans. 2020 Jan 2;49(2):279-284. doi: 10.1039/c9dt04558a.
6
Improved pH measurements with a single PARACEST MRI contrast agent.一种 PARACEST MRI 对比剂可改善 pH 值测量。
Contrast Media Mol Imaging. 2012 Jan-Feb;7(1):26-34. doi: 10.1002/cmmi.460.
7
The NiCEST approach: nickel(II) paraCEST MRI contrast agents.NiCEST 方法：镍（II）顺磁 CEST MRI 对比剂。
J Am Chem Soc. 2012 Nov 14;134(45):18503-5. doi: 10.1021/ja307909x. Epub 2012 Nov 2.
8
The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent.LnDOTA-四酰胺配合物中-NH 交换的 pH 敏感性随酰胺取代基而变化。
Contrast Media Mol Imaging. 2011 Nov-Dec;6(6):459-64. doi: 10.1002/cmmi.445.
9
A Frequency-Selective pH-Responsive paraCEST Agent.一种频率选择型 pH 响应性 paraCEST 造影剂。
Angew Chem Int Ed Engl. 2020 Nov 23;59(48):21671-21676. doi: 10.1002/anie.202008888. Epub 2020 Oct 6.
10
Iron(II) PARACEST MRI contrast agents.亚铁(II) 类 PARACEST MRI 对比剂。
J Am Chem Soc. 2011 Sep 14;133(36):14154-6. doi: 10.1021/ja204297z. Epub 2011 Aug 18.
引用本文的文献
1
Controlling the Redox Chemistry of Cobalt Radiopharmaceuticals.控制钴放射性药物的氧化还原化学
Angew Chem Int Ed Engl. 2024 Dec 9;63(50):e202412357. doi: 10.1002/anie.202412357. Epub 2024 Nov 5.
2
Endeavor toward Redox-Responsive Transition Metal Contrast Agents Based on the Cross-Bridge Cyclam Platform.基于跨桥环胺平台的氧化还原响应型过渡金属造影剂的研究进展
Inorg Chem. 2024 Jan 22;63(3):1575-1588. doi: 10.1021/acs.inorgchem.3c03486. Epub 2024 Jan 10.
3
NMR exchange dynamics studies of metal-capped cyclodextrins reveal multiple populations of host-guest complexes in solution.金属封端环糊精的核磁共振交换动力学研究揭示了溶液中主体-客体复合物的多种存在形式。
Chem Sci. 2023 Sep 7;14(41):11351-11358. doi: 10.1039/d3sc03630h. eCollection 2023 Oct 25.
4
Lanthanide(III) Complexes Based on an 18-Membered Macrocycle Containing Acetamide Pendants. Structural Characterization and paraCEST Properties.基于含乙酰酰胺支链的 18 员大环的镧系（III）配合物。结构表征和 paraCEST 属性。
Inorg Chem. 2021 Feb 1;60(3):1902-1914. doi: 10.1021/acs.inorgchem.0c03385. Epub 2021 Jan 20.
5
From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges.基于金属探针的磁共振成像从锌（II）到铜（II）的检测：当前进展与挑战
Pharmaceuticals (Basel). 2020 Nov 30;13(12):436. doi: 10.3390/ph13120436.
6
Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging.过渡金属化学在对比增强磁共振成像中的应用。
Inorg Chem. 2020 May 18;59(10):6648-6678. doi: 10.1021/acs.inorgchem.0c00510. Epub 2020 May 5.
7
Isomeric Co(ii) paraCEST agents as pH responsive MRI probes.同型 Co(ii) 顺磁 CEST 试剂作为 pH 响应 MRI 探针。
Dalton Trans. 2020 Jan 2;49(2):279-284. doi: 10.1039/c9dt04558a.
8
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.磁共振成像对比剂的化学：当前的挑战与新前沿。
Chem Rev. 2019 Jan 23;119(2):957-1057. doi: 10.1021/acs.chemrev.8b00363. Epub 2018 Oct 16.
9
Biomolecular MRI reporters: Evolution of new mechanisms.生物分子 MRI 报告器：新机制的演进。
Prog Nucl Magn Reson Spectrosc. 2017 Nov;102-103:32-42. doi: 10.1016/j.pnmrs.2017.05.002. Epub 2017 Jun 3.
10
Cellular and Molecular Imaging Using Chemical Exchange Saturation Transfer.利用化学交换饱和转移的细胞与分子成像
Top Magn Reson Imaging. 2016 Oct;25(5):197-204. doi: 10.1097/RMR.0000000000000105.
本文引用的文献
1
The NiCEST approach: nickel(II) paraCEST MRI contrast agents.NiCEST 方法：镍（II）顺磁 CEST MRI 对比剂。
J Am Chem Soc. 2012 Nov 14;134(45):18503-5. doi: 10.1021/ja307909x. Epub 2012 Nov 2.
2
Iron(II) complexes containing octadentate tetraazamacrocycles as paraCEST magnetic resonance imaging contrast agents.含八齿四面体型四氮杂大环配体的二价铁配合物作为 paraCEST 磁共振成像对比剂。
Inorg Chem. 2012 Jul 16;51(14):7448-50. doi: 10.1021/ic301001u. Epub 2012 Jul 3.
3
Copper and cobalt complexes of octadentate azamacrocycles: spectrophotometric titration, stopped-flow kinetics and crystallographic study.八齿氮杂大环铜钴配合物的光谱滴定、停流动力学及晶体结构研究。
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Dec;83(1):525-31. doi: 10.1016/j.saa.2011.08.078. Epub 2011 Sep 9.
4
Iron(II) PARACEST MRI contrast agents.亚铁(II) 类 PARACEST MRI 对比剂。
J Am Chem Soc. 2011 Sep 14;133(36):14154-6. doi: 10.1021/ja204297z. Epub 2011 Aug 18.
5
Alternatives to gadolinium-based metal chelates for magnetic resonance imaging.用于磁共振成像的钆基金属螯合物的替代物
Chem Rev. 2010 May 12;110(5):2960-3018. doi: 10.1021/cr900284a.
6
Correlation of relaxivity with coordination number in six-, seven-, and eight-coordinate Mn(II) complexes of pendant-arm cyclen derivatives.侧臂环糊精衍生物的六配位、七配位和八配位锰（II）配合物中弛豫率与配位数的相关性。
Inorg Chem. 2009 Jan 19;48(2):719-27. doi: 10.1021/ic8003068.
7
Seven-coordination versus six-coordination in divalent first-row transition-metal complexes derived from 1,10-diaza-15-crown-5.源自1,10-二氮杂-15-冠-5的二价第一周期过渡金属配合物中的七配位与六配位
Inorg Chem. 2007 Oct 1;46(20):8271-82. doi: 10.1021/ic7008946. Epub 2007 Sep 1.
8
Paramagnetic lanthanide complexes as PARACEST agents for medical imaging.作为用于医学成像的顺磁镧系元素配合物的PARACEST试剂
Chem Soc Rev. 2006 Jun;35(6):500-11. doi: 10.1039/b509907m. Epub 2006 May 10.
9
NMR spectroscopy of paramagnetic metalloproteins.顺磁金属蛋白的核磁共振光谱学。
Chembiochem. 2005 Sep;6(9):1536-49. doi: 10.1002/cbic.200500124.
10
PARACEST agents: modulating MRI contrast via water proton exchange.PARACEST造影剂：通过水质子交换调节磁共振成像对比
Acc Chem Res. 2003 Oct;36(10):783-90. doi: 10.1021/ar020228m.
Zotero 插件