Zn 掺杂纳米晶须羟基磷灰石涂层改性镁合金的耐腐蚀性和生物活性增强。
Enhanced corrosion resistance and bioactivity of Mg alloy modified by Zn-doped nanowhisker hydroxyapatite coatings.
机构信息
Department of Oral & Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, China; Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine Jiangxi Province, Medical College of Nanchang University, Nanchang 330006, China.
Weifang Medical University School of Stomatology, Weifang 261053, China.
出版信息
Colloids Surf B Biointerfaces. 2020 Feb;186:110710. doi: 10.1016/j.colsurfb.2019.110710. Epub 2019 Dec 5.
In this work, Zn is doped into a hydroxyapatite coating on the surface of ZK60 magnesium alloys using a one-pot hydrothermal method to obtain a corrosion-resistant implant with abilities of osteogenic differentiation and bacterial inhibition. With the addition of Zn, the morphology changes with a nanowhisker structure appearing on the coating. Electrochemical measurements show that the nanowhisker hydroxyapatite coating provides a high corrosion resistance. Compared with hydroxyapatite coating, the nanowhisker coating not only effectively inhibits bacteria, but also promotes the adhesion and differentiation of rat bone marrow mesenchymal stem cells at appropriate Zn concentrations. In conclusion, a novel nanowhisker structure prepared by a single variable Zn doping can significantly improve the corrosion resistance and biological activity of hydroxyapatite coatings.
在这项工作中，通过一锅水热法将 Zn 掺杂到 ZK60 镁合金表面的羟基磷灰石涂层中，获得了一种具有成骨分化和抑制细菌能力的耐腐蚀植入物。随着 Zn 的加入，涂层的形貌发生变化，出现纳米线结构。电化学测量表明，纳米线羟基磷灰石涂层具有高耐腐蚀性。与羟基磷灰石涂层相比，纳米线涂层不仅能有效抑制细菌，而且在适当的 Zn 浓度下还能促进大鼠骨髓间充质干细胞的黏附和分化。总之，通过单一变量 Zn 掺杂制备的新型纳米线结构可以显著提高羟基磷灰石涂层的耐腐蚀性和生物活性。
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