Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Yeonjudanji-ro 30, Chungbuk 28116, Korea.
Department of Animal Science and Technology, Chung-Ang University, Seodong-daero 4726, Gyeonggi 17546, Korea.
Int J Med Sci. 2019 Oct 21;16(12):1557-1563. doi: 10.7150/ijms.39068. eCollection 2019.
E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. The purpose of this study, was to investigate the role and function of E2F3 . We examined phenotypic abnormalities, by deletion of the gene in mice. Complete ablation of the E2F3 was fully penetrant, in the pure C57BL/6N background. The mouse embryo developed normally without fatal disorder. However, they exhibited reduced body weight, growth retardation, skeletal imperfection, and poor grip strength ability. Findings suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.
E2F3 是 E2F 家族的一员，通过靶向下游视网膜母细胞瘤（RB）抑癌家族蛋白在细胞周期和增殖中发挥关键作用。本研究旨在探讨 E2F3 的作用和功能。我们通过在小鼠中缺失基因来检查表型异常。在纯 C57BL/6N 背景下，E2F3 的完全缺失是完全显性的。E2F3 缺失的小鼠胚胎发育正常，没有致命障碍。然而，它们表现出体重减轻、生长迟缓、骨骼畸形和握力能力差。研究结果表明，E2F3 在肌肉和骨骼发育中具有关键作用，并影响正常小鼠的生长。
