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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Simon L M, Robin E D, Theodore J

Department of Medicine, Stanford University School of Medicine, CA.

Comp Biochem Physiol B. 1979;63(2):283-5. doi: 10.1016/0305-0491(79)90041-5.

The effect of sustained (48 hr) oxygen depletion on tissue (brain, heart, skeletal muscle) pyruvate kinase (PyKi) activities was examined in the pond turtle (Pseudemys scripta elegans). 2. PyKi activities in skeletal muscle are significantly increased (from 322 +/- 84 to 450 +/- 95) following 48 hr of tissue hypoxia. PyKi activities in brain may already be elevated under ambient conditions but do not change following prolonged submersion (334 +/- 75 vs 325 +/- 77). Cardiac muscle PyKi is actually decreased (from 135 +/- 35 to 94 +/- 18) under anaerobic conditions. 3. The data suggest that prolonged O2 depletion may increase PyKi biosynthesis in turtle skeletal muscle (subserving enhanced glycolysis), but also demonstrate that factors other than oxygen availability are involved in the regulation of tissue PyKi activities in intact vertebrates.

在池龟（秀丽锦龟）中研究了持续（48小时）缺氧对组织（脑、心脏、骨骼肌）丙酮酸激酶（PyKi）活性的影响。2. 组织缺氧48小时后，骨骼肌中的PyKi活性显著增加（从322±84增加到450±95）。脑内的PyKi活性在环境条件下可能已经升高，但长时间浸没后并无变化（334±75对325±77）。在无氧条件下，心肌中的PyKi实际上降低了（从135±35降至94±18）。3. 数据表明，长时间缺氧可能会增加龟骨骼肌中PyKi的生物合成（有助于增强糖酵解），但也表明在完整的脊椎动物中，除了氧的可利用性外，其他因素也参与组织PyKi活性的调节。

Simon L M, Robin E D, Theodore J

Department of Medicine, Stanford University School of Medicine, CA.

Comp Biochem Physiol B. 1979;63(2):283-5. doi: 10.1016/0305-0491(79)90041-5.

The effect of sustained (48 hr) oxygen depletion on tissue (brain, heart, skeletal muscle) pyruvate kinase (PyKi) activities was examined in the pond turtle (Pseudemys scripta elegans). 2. PyKi activities in skeletal muscle are significantly increased (from 322 +/- 84 to 450 +/- 95) following 48 hr of tissue hypoxia. PyKi activities in brain may already be elevated under ambient conditions but do not change following prolonged submersion (334 +/- 75 vs 325 +/- 77). Cardiac muscle PyKi is actually decreased (from 135 +/- 35 to 94 +/- 18) under anaerobic conditions. 3. The data suggest that prolonged O2 depletion may increase PyKi biosynthesis in turtle skeletal muscle (subserving enhanced glycolysis), but also demonstrate that factors other than oxygen availability are involved in the regulation of tissue PyKi activities in intact vertebrates.

在池龟（秀丽锦龟）中研究了持续（48小时）缺氧对组织（脑、心脏、骨骼肌）丙酮酸激酶（PyKi）活性的影响。2. 组织缺氧48小时后，骨骼肌中的PyKi活性显著增加（从322±84增加到450±95）。脑内的PyKi活性在环境条件下可能已经升高，但长时间浸没后并无变化（334±75对325±77）。在无氧条件下，心肌中的PyKi实际上降低了（从135±35降至94±18）。3. 数据表明，长时间缺氧可能会增加龟骨骼肌中PyKi的生物合成（有助于增强糖酵解），但也表明在完整的脊椎动物中，除了氧的可利用性外，其他因素也参与组织PyKi活性的调节。