神经相关性应激与冠状动脉疾病患者腹部肥胖。
Neural Correlates of Stress and Abdominal Obesity in Patients With Coronary Artery Disease.
机构信息
From the Department of Epidemiology (Moazzami, Lima, Levantsevych, Kaseer, Martini, Haffar, Shah, Vaccarino), Rollins School of Public Health, Emory University; Emory Clinical Cardiovascular Research Institute (Moazzami, Lima, Levantsevych, Kaseer, Martini, Haffar, Quyyumi, Shah, Vaccarino), Department of Medicine, Division of Cardiology, Emory University School of Medicine; Department of Psychiatry and Behavioral Sciences (Wittbrodt, Bremner), and Department of Radiology and Imaging Sciences (Nye, Bremner), Emory University School of Medicine, Atlanta; and Atlanta VA Medical Center (Shah, Bremner), Decatur, Gerogia.
出版信息
Psychosom Med. 2020 Apr;82(3):272-280. doi: 10.1097/PSY.0000000000000776.
OBJECTIVE
This study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD).
METHODS
Patients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron emission tomography and radiolabeled water imaging of the brain. Brain responses to mental stress were correlated with waist circumference.
RESULTS
Waist circumference was positively correlated with increased activation in the right and left frontal lobes (β values ranging from 2.81 to 3.75 in the paracentral, medial, and superior gyri), left temporal lobe, left hippocampal, left amygdala, left uncus, and left anterior and posterior cingulate gyri (β values ranging from 2.93 to 3.55). Waist circumference was also negatively associated with the left and right parietal lobes, right superior temporal gyrus, and right insula and precuneus (β values ranging from 2.82 to 5.20).
CONCLUSION
Increased brain activation in the brain regions involved in the stress response and autonomic regulation of the cardiovascular system during psychological stress may underlie stress-induced overeating and abdominal obesity in patients with CAD.
目的
本研究旨在探讨冠心病（CAD）患者腰围作为腹型肥胖指标与大脑对应激反应的关系。
方法
151 例 CAD 患者接受急性心理应激任务，同时进行高分辨率正电子发射断层扫描和脑放射性水成像。将大脑对应激的反应与腰围相关联。
结果
腰围与大脑右额叶和左额叶（旁中央、内侧和上回的β 值范围为 2.81 至 3.75）、左颞叶、左海马体、左杏仁核、左钩回和左前后扣带回（β 值范围为 2.93 至 3.55）的激活增加呈正相关。腰围也与左右顶叶、右颞上回和右岛叶及楔前叶（β 值范围为 2.82 至 5.20）呈负相关。
结论
在心理应激期间，与应激反应和心血管系统自主调节相关的大脑区域的大脑激活增加，可能是 CAD 患者应激诱导过度进食和腹型肥胖的基础。
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