Pereira Gabriela Caparica Muniz, de Oliveira Gustavo Carvalho
Acadêmica de Medicina do Centro Universitário de Brasília - UniCeub, DF, Brazil.
Professor Adjunto do Centro Universitário de Brasília - Uniceub, DF, Brazil.
Dement Neuropsychol. 2019 Oct-Dec;13(4):463-468. doi: 10.1590/1980-57642018dn13-040014.
The association between Capgras syndrome and Alzheimer's disease has been reported in several studies, but its prevalence varies considerably in the literature, making it difficult to measure and manage this condition.
This study aims to estimate the prevalence of Capgras syndrome in patients with Alzheimer's disease through a systematic review, and to review etiological and pathophysiological aspects related to the syndrome.
A systematic review was conducted using the Medline, ISI, Cochrane, Scielo, Lilacs, and Embase databases. Two independent researchers carried out study selection, data extraction, and qualitative analysis by strictly following the same methodology. Disagreements were resolved by consensus. The meta-analysis was performed using the random effect model.
40 studies were identified, 8 of which were included in the present review. Overall, a total of 1,977 patients with Alzheimer's disease were analyzed, and the prevalence of Capgras syndrome in this group was 6% (CI: 95% I² 54% 4.0-8.0).
The study found a significant prevalence of Capgras syndrome in patients with Alzheimer's disease. These findings point to the need for more studies on the topic to improve the management of these patients.
多项研究报道了卡普格拉综合征与阿尔茨海默病之间的关联，但该综合征在文献中的患病率差异很大，这使得对其进行测量和管理变得困难。
本研究旨在通过系统评价估计阿尔茨海默病患者中卡普格拉综合征的患病率，并回顾与该综合征相关的病因学和病理生理学方面。
使用Medline、ISI、Cochrane、Scielo、Lilacs和Embase数据库进行系统评价。两名独立研究人员严格遵循相同方法进行研究选择、数据提取和定性分析。分歧通过协商解决。采用随机效应模型进行荟萃分析。
共识别出40项研究，其中8项纳入本综述。总体而言，共分析了1977例阿尔茨海默病患者，该组中卡普格拉综合征的患病率为6%（置信区间：95%，I² 54%，4.0 - 8.0）。
该研究发现阿尔茨海默病患者中卡普格拉综合征的患病率较高。这些发现表明需要对该主题进行更多研究，以改善对这些患者的管理。
