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丙二酰辅酶A脱羧酶的双重发生位点及其在禽类组织中的可能功能意义。

Dual sites of occurrence of malonyl-CoA decarboxylase and their possible functional significance in avian tissues.

作者信息

Kim Y S, Kolattukudy P E, Boos A

机构信息

Department of Agricultural Chemistry, Washington State University, Pullman 99164.

出版信息

Comp Biochem Physiol B. 1979;62(4):443-7. doi: 10.1016/0305-0491(79)90115-9.

DOI:10.1016/0305-0491(79)90115-9
PMID:318451
Abstract
  1. Uropygial glands of domestic goose and mallard which synthesize methyl-branched fatty acids, contain large quantities of cytosolic malonyl-CoA decarboxylase and a small quantity of mitochondrial enzyme. 2. Uropygial glands of chicken and the liver of geese which generate little methyl-branched acids, contain only small quantities of malonyl-CoA decarboxylase and in such cases the enzyme is in the mitochondria. 3. The mitochondrial decarboxylase from the uropygial gland and liver of goose is immunologically similar to the cytosolic decarboxylase of the uropygial gland. 4. The mitochondrial enzyme probably protects the mitochondrial enzymes which are susceptible to inhibition by malonyl-CoA, whereas the cytosolic enzyme promotes the synthesis of methyl-branched acids.
摘要
  1. 家鹅和野鸭的尾脂腺能合成甲基支链脂肪酸,含有大量的胞质丙二酰辅酶A脱羧酶和少量的线粒体酶。2. 鸡的尾脂腺和鹅的肝脏产生很少的甲基支链酸,只含有少量的丙二酰辅酶A脱羧酶,且在这种情况下该酶存在于线粒体中。3. 鹅尾脂腺和肝脏中的线粒体脱羧酶与尾脂腺的胞质脱羧酶在免疫学上相似。4. 线粒体酶可能保护易受丙二酰辅酶A抑制的线粒体酶,而胞质酶则促进甲基支链酸的合成。

相似文献

1
Dual sites of occurrence of malonyl-CoA decarboxylase and their possible functional significance in avian tissues.丙二酰辅酶A脱羧酶的双重发生位点及其在禽类组织中的可能功能意义。
Comp Biochem Physiol B. 1979;62(4):443-7. doi: 10.1016/0305-0491(79)90115-9.
2
Cytoplasmic accumulation of a normally mitochondrial malonyl-CoA decarboxylase by the use of an alternate transcription start site.通过使用一个替代转录起始位点,正常定位于线粒体的丙二酰辅酶A脱羧酶在细胞质中积累。
Arch Biochem Biophys. 1992 Nov 1;298(2):576-86. doi: 10.1016/0003-9861(92)90452-3.
3
Molecular cloning, nucleotide sequence, and tissue distribution of malonyl-CoA decarboxylase.丙二酰辅酶A脱羧酶的分子克隆、核苷酸序列及组织分布
J Biol Chem. 1989 Feb 25;264(6):3500-5.
4
Developmental pattern of the expression of malonyl-CoA decarboxylase gene and the production of unique lipids in the goose uropygial glands.鹅尾脂腺中丙二酰辅酶A脱羧酶基因表达的发育模式及独特脂质的产生
Arch Biochem Biophys. 1987 Aug 1;256(2):446-54. doi: 10.1016/0003-9861(87)90601-1.
5
Lipid biosynthesis in sebaceous glands: regulation of the synthesis of n- and branched fatty acids by malonyl-coenzyme A decarboxylase.皮脂腺中的脂质生物合成:丙二酰辅酶A脱羧酶对正脂肪酸和支链脂肪酸合成的调节
Biochemistry. 1975 Apr 22;14(8):1768-73. doi: 10.1021/bi00679a032.
6
Synthesis of multimethyl-branched fatty acids by avian and mammalian fatty acid synthetase and its regulation by malonyl-CoA decarboxylase in the uropygial gland.鸟类和哺乳动物脂肪酸合成酶合成多甲基支链脂肪酸及其在尾脂腺中受丙二酸单酰辅酶A脱羧酶的调控
Arch Biochem Biophys. 1978 Feb;186(1):152-63. doi: 10.1016/0003-9861(78)90474-5.
7
Malonyl-CoA decarboxylase from the uropygial gland of waterfowl: purification, properties, immunological comparison, and role in regulating the synthesis of multimethyl-branched fatty acids.水鸟尾脂腺中丙二酸单酰辅酶A脱羧酶:纯化、性质、免疫比较及在调节多甲基支链脂肪酸合成中的作用
Arch Biochem Biophys. 1978 Oct;190(2):585-97. doi: 10.1016/0003-9861(78)90314-4.
8
Stereospecificity of malonyl-CoA decarboxylase, acetyl-CoA carboxylase, and fatty acid synthetase from the uropygial gland of goose.鹅尾脂腺中丙二酰辅酶A脱羧酶、乙酰辅酶A羧化酶和脂肪酸合成酶的立体特异性
J Biol Chem. 1980 Jan 25;255(2):686-9.
9
Malonyl-CoA decarboxylase from avian, mammalian, and microbial sources.来自鸟类、哺乳动物和微生物的丙二酰辅酶A脱羧酶。
Methods Enzymol. 1981;71 Pt C:150-63. doi: 10.1016/0076-6879(81)71022-x.
10
Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes.丙二酰辅酶A脱羧酶存在于大鼠肝细胞的胞质、线粒体和过氧化物酶体区室中。
FEBS Lett. 2005 Dec 5;579(29):6581-6. doi: 10.1016/j.febslet.2005.10.050. Epub 2005 Nov 9.

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Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.过氧化物酶体增殖物激活受体α激活大鼠肝脏丙二酰辅酶A脱羧酶基因的转录:丙二酰辅酶A水平的关键调控
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