Isouard G
Radioisotope Laboratory, Canterbury Hospital, N.S.W.
Med J Aust. 1979 Oct 20;2(8):401-4. doi: 10.5694/j.1326-5377.1979.tb104207.x.
Maternal serum levels of total oestriol and human placental lactogen (HPL) were measured in 280 normal and 87 pre-eclamptic pregnancies. Normal levels of HPL, but significantly reduced total oestriol values were obtained when pre-eclampsia was present. However, when fetal complications developed, both hormone levels were further significantly reduced. The severity of pre-eclampsia had no effect on the serum levels of oestriol and HPL. An analysis of the 18 pregnancies with significant fetal-placental dysfunction showed that 13 (72%) were predicted by unfavourable levels of total oestriol, nine (50%) by unfavourable levels of HPL, and 14 (78%) by the use of both assays. The present study supports the value of antenatal measurement both of serum total oestriol and of HPL in the management of pre-eclamptic pregnancies.
对280例正常妊娠和87例先兆子痫妊娠的孕妇血清总雌三醇和人胎盘催乳素（HPL）水平进行了测定。当存在先兆子痫时，HPL水平正常，但总雌三醇值显著降低。然而，当出现胎儿并发症时，两种激素水平进一步显著降低。先兆子痫的严重程度对雌三醇和HPL的血清水平没有影响。对18例有明显胎儿-胎盘功能障碍的妊娠进行分析发现，13例（72%）可通过总雌三醇水平异常预测，9例（50%）可通过HPL水平异常预测，14例（78%）可通过两种检测方法预测。本研究支持在先兆子痫妊娠管理中进行血清总雌三醇和HPL产前检测的价值。
