Department of ENT, All India Institute of Medical Sciences, Bhubaneshwar, India.
Department of Pathology, All India Institute of Medical Sciences, Bhubaneshwar, India.
Lupus. 2020 Feb;29(2):210-212. doi: 10.1177/0961203319894371. Epub 2019 Dec 17.
Although the association of discoid lupus erythematosus (DLE) with squamous cell carcinoma has been described in the literature, coexistence with a basal cell carcinoma is very rare. The indolent and non-pruritic nature of the lesion cause it often to be diagnosed at the late stage of the disease. Long-standing photosensitivity and chronic inflammation later lead to scarring and hypopigmentation, which are considered as the risk factors for the malignant changes over DLE. Incisional biopsy is often performed from the erythematosus lesion which does not respond to medical treatment. Here we have reported a rare case of basal cell carcinoma of the skin developing in the background of long-standing DLE, which was successfully managed with cold knife local excision.
虽然盘状红斑狼疮（DLE）与鳞状细胞癌相关的关联在文献中有描述，但与基底细胞癌共存的情况非常罕见。病变的慢性、非瘙痒性导致其经常在疾病晚期才被诊断出来。长期的光敏感和慢性炎症后会导致瘢痕和色素减退，这些被认为是 DLE 恶变的危险因素。红斑病变对药物治疗无反应时，常进行切开活检。我们报告了一例罕见的长期 DLE 背景下发生的基底细胞癌，通过冷刀局部切除成功治疗。
