Kim Kyung Min, Kim Jiyoung, Cho Soo-Jin, Kim Won-Joo, Yang Kwang Ik, Yun Chang-Ho, Chu Min Kyung
Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Department of Neurology, Bio Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.
Front Neurol. 2019 Dec 3;10:1282. doi: 10.3389/fneur.2019.01282. eCollection 2019.
Excessive daytime sleepiness (EDS) is a prevalent sleep-related complaint across the general population and has been reported to be associated with headache. Tension-type headache (TTH) is the most commonly encountered headache and accounts for a significant amount of disease burden. However, the association between EDS and TTH is currently scarce. In the present study, we investigated the impact of EDS on the prevalence and clinical presentation of TTH. We utilized data from the Korean Headache-Sleep Study, a national survey that sought to identify headache and sleep characteristics in Korean adults. Participants with an Epworth sleepiness scale score greater or equal to 11 were considered as having EDS. Of the 2,695 participants enrolled, 570 (21.2%) and 313 (11.6%) had TTH and EDS, respectively. EDS was highly prevalent in individuals with chronic tension-type headache (CTTH) than in those without headache (35.7 vs. 9.4%, < 0.001). The prevalence of EDS in episodic tension-type headache (ETTH) individuals with a headache frequency <1 per month (8.3%, = 0.511) and ETTH individuals with a headache frequency of 1-14 per month (13.5%, = 0.054) was not significantly different from that in individuals without headache (9.4%). TTH participants with EDS had a higher headache frequency per month (4.3 ± 8.1 vs. 1.7 ± 4.2, = 0.013), more severe headache intensity (Visual Analog Scale, 5.0 [3.0-6.0] vs. 4.0 [3.0-6.0], = 0.008), a higher impact of headache (Headache Impact Test-6 score, 47.1 ± 7.3 vs. 43.5 ± 7.6, < 0.001), and a higher prevalence of depression (12.7 vs. 3.2%, < 0.001) than TTH participants without EDS. Consequently, CTTH is associated with higher EDS prevalence compared to ETTH and without headache. Moreover, TTH with EDS had more severe TTH symptoms compared to TTH without EDS.
日间过度嗜睡(EDS)是普通人群中常见的与睡眠相关的主诉,据报道与头痛有关。紧张型头痛(TTH)是最常见的头痛类型,造成了大量的疾病负担。然而,目前关于EDS与TTH之间的关联研究较少。在本研究中,我们调查了EDS对TTH患病率和临床表现的影响。我们利用了韩国头痛-睡眠研究的数据,这是一项旨在确定韩国成年人头痛和睡眠特征的全国性调查。Epworth嗜睡量表评分大于或等于11分的参与者被视为患有EDS。在纳入的2695名参与者中,分别有570人(21.2%)和313人(11.6%)患有TTH和EDS。与无头痛者相比,慢性紧张型头痛(CTTH)患者中EDS的患病率更高(35.7%对9.4%,<0.001)。每月头痛发作频率<1次的发作性紧张型头痛(ETTH)患者(8.3%,=0.511)和每月头痛发作频率为1-14次的ETTH患者(13.5%,=0.054)中EDS的患病率与无头痛者(9.4%)相比无显著差异。患有EDS的TTH参与者每月头痛发作频率更高(4.3±8.1对1.7±4.2,=0.013),头痛强度更严重(视觉模拟量表,5.0[3.0-6.0]对4.0[3.0-6.0],=0.008),头痛影响更大(头痛影响测试-6评分,47.1±7.3对43.5±7.6,<0.001),且抑郁症患病率更高(12.7%对3.2%,<0.001)。因此,与ETTH和无头痛者相比,CTTH与更高的EDS患病率相关。此外,与无EDS的TTH相比,患有EDS的TTH症状更严重。