Kim Jiyoung, Cho Soo-Jin, Kim Won-Joo, Yang Kwang Ik, Yun Chang-Ho, Chu Min Kyung
Department of Neurology, Bio Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.
Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, South Korea.
J Headache Pain. 2016 Dec;17(1):62. doi: 10.1186/s10194-016-0655-4. Epub 2016 Jul 1.
Previous studies have shown that migraine and sleep disturbances are closely associated. Excessive daytime sleepiness (EDS) is a common symptom of various types of sleep disturbance. Findings from clinic-based studies suggest that a high percentage of migraineurs experience EDS. However, the prevalence and clinical impact of EDS among migraineurs at the population level have rarely been reported. The objective of this study was to investigate the prevalence and impact of EDS among migraineurs using a population-based sample in Korea.
We selected a stratified random sample of Koreans aged 19 to 69 years and evaluated them using a semi-structured interview designed to identify EDS, headache type, and the clinical characteristics of migraine. If the score on the Epworth Sleepiness Scale (ESS) was more than or equal to 11, the participant was classified as having EDS.
Of the 2,695 participants that completed the interview, 143 (5.3 %) and 313 (11.6 %) were classified as having migraine and EDS, respectively. The prevalence of EDS was significantly higher in participants with migraine (19.6 %) and non-migraine headache (13.4 %) compared to non-headache controls (9.4 %). Migraineurs with EDS had higher scores on the Visual Analogue Scale (VAS) for headache intensity (6.9 ± 1.8 vs. 6.0 ± 1.9, p = 0.014) and Headache Impact Test-6 (59.8 ± 10.2 vs. 52.5 ± 8.2, p < 0.001) compared to migraineurs without EDS.
Approximately 20 % of migraineurs had EDS in this population-based sample. Excessive daytime sleepiness was associated with an exacerbation of some migraine symptoms.
先前的研究表明偏头痛与睡眠障碍密切相关。日间过度嗜睡（EDS）是各类睡眠障碍的常见症状。基于临床研究的结果表明，很大比例的偏头痛患者存在日间过度嗜睡。然而，在人群层面上，偏头痛患者中EDS的患病率及其临床影响鲜有报道。本研究的目的是利用韩国的一个基于人群的样本，调查偏头痛患者中EDS的患病率及其影响。
我们选取了19至69岁韩国人的分层随机样本，并使用旨在识别EDS、头痛类型和偏头痛临床特征的半结构化访谈对他们进行评估。如果爱泼沃斯思睡量表（ESS）得分大于或等于11分，则参与者被归类为患有EDS。
在完成访谈的2695名参与者中，分别有143名（5.3%）和313名（11.6%）被归类为患有偏头痛和EDS。与无头痛对照组（9.4%）相比，偏头痛患者（19.6%）和非偏头痛性头痛患者（13.4%）中EDS的患病率显著更高。与无EDS的偏头痛患者相比，有EDS的偏头痛患者在头痛强度视觉模拟量表（VAS）上得分更高（6.9±1.8对6.0±1.9，p = 0.014），在头痛影响测试-6（HIT-6）上得分也更高（59.8±10.2对52.5±8.2，p < 0.001）。
在这个基于人群的样本中，约20%的偏头痛患者患有EDS。日间过度嗜睡与某些偏头痛症状的加重有关。
