Scala Jacopo, Vojvodic Aleksandra, Vojvodic Petar, Vlaskovic-Jovicevic Tatjana, Peric-Hajzler Zorica, Matovic Dusica, Dimitrijevic Sanja, Vojvodic Jovana, Sijan Goran, Stepic Nenad, Wollina Uwe, Tirant Michael, Thuong Nguyen Van, Fioranelli Massimo, Lotti Torello
University G. Marconi, Rome, Italy.
Department of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia.
Open Access Maced J Med Sci. 2019 Aug 30;7(18):2979-2981. doi: 10.3889/oamjms.2019.783. eCollection 2019 Sep 30.
Botulinum toxin (BTX) is a neurotoxin protein derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions which include scar prevention and treatment with good results The complex mechanism underlying those results is not completely understood but several mechanisms were proposed release inhibition of different substances like (TGF)-β, substance P, calcitonin gene-related peptide (CGRP) and glutamate thus modulating cutaneous inflammation and wound healing. We analysed the published data on BTX off label applications on scars and keloids retrieved from PubMed.
肉毒杆菌毒素（BTX）是一种源自肉毒杆菌的神经毒素蛋白，它在神经肌肉接头水平抑制乙酰胆碱的释放，其作用多年来一直用于治疗各种肌肉/神经肌肉疾病，最近也用于美容用途。BTX已在一些皮肤病学病症中进行了试验，包括瘢痕预防和治疗，取得了良好效果。这些结果背后的复杂机制尚未完全了解，但有人提出了几种机制，即抑制不同物质如（转化生长因子）-β、P物质、降钙素基因相关肽（CGRP）和谷氨酸的释放，从而调节皮肤炎症和伤口愈合。我们分析了从PubMed检索到的关于BTX在瘢痕和瘢痕疙瘩的非标签应用的已发表数据。
