Hise M K, Mehta P
Division of Nephrology, University of Maryland, Baltimore 21201.
Life Sci. 1988;43(18):1479-83. doi: 10.1016/0024-3205(88)90260-3.
The activity of the calcium sensitive phospholipid dependent protein kinase C (PKC) was studied in cytosol and in the proximal tubular luminal membrane of rats during growth. Cytosolic activity was elevated at 14 and 21 days of age and fell to adult levels by day 60. Luminal brush border membrane activity on the other hand was low on day 14 but reached adult levels by day 21. Changes in brush border membrane PKC activity may have important consequences for the development of electrolyte transport in proximal tubular cells.
在生长过程中，对大鼠的细胞溶质以及近端肾小管腔膜中钙敏感的磷脂依赖性蛋白激酶C（PKC）的活性进行了研究。细胞溶质活性在14日龄和21日龄时升高，到60日龄时降至成年水平。另一方面，管腔刷状缘膜活性在14日龄时较低，但在21日龄时达到成年水平。刷状缘膜PKC活性的变化可能对近端肾小管细胞中电解质转运的发育产生重要影响。
