用外膜囊泡免疫后与巴西B菌株的交叉反应性。
Cross-reactivity with Brazilian strains of B after immunization with outer membrane vesicles.
作者信息
Trzewikoswki de Lima Gabriela, Portilho Amanda Izeli, De Gaspari Elizabeth
机构信息
Departamento de Imunologia, Instituto Adolfo Lutz, São Paulo, SP, Brasil.
Departamento de Imunologia, Instituto Adolfo Lutz, Av. Dr. Arnaldo, 355, 11° andar, sala 1116, Cerqueira César, São Paulo, SP 01246-902, Brasil.
出版信息
Ther Adv Vaccines Immunother. 2019 Dec 11;7:2515135519894825. doi: 10.1177/2515135519894825. eCollection 2019.
BACKGROUND
Immunization against is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection.
METHODS
The cross-reactivity between three strains from the last outbreak of in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays.
RESULTS
Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated.
CONCLUSIONS
We observed that immunization with B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains.
背景
针对[疾病名称]的免疫接种对公共卫生很重要。由交叉反应抗原组成的疫苗可避免菌株特异性反应，确保更全面的保护。
方法
在我们的研究中，使用酶联免疫吸附测定（ELISA）和免疫印迹测定评估了巴西上次[疾病名称]疫情中三个菌株之间的交叉反应性。
结果
两种测定均验证了所评估菌株之间类似的体液反应。抗原识别模式因所评估的每种剂量而异。
结论
我们观察到，用[细菌名称]B外膜囊泡（OMV）免疫接种会导致产生识别异源菌株抗原的抗体，表明可能对这些评估菌株具有保护作用。
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