Shanghai Institute for Minimally Invasive Therapy, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Int J Hyperthermia. 2019;36(1):1297-1306. doi: 10.1080/02656736.2019.1702723.
A control algorithm for radio-frequency-induced intestinal tissue fusion was developed to explore the effects of different control parameters on intestinal tissue fusion. Radio-frequency-induced fusion was performed on small intestine tissue. The effect on the fusion was observed by changing the control parameters (power, interval time, and terminal impedance) in the algorithm. The quality of fusion was evaluated using the burst pressure and thermal damage measurement. Histological evaluation was used to assess the fusion quality indirectly. A maximum burst pressure of 8.460 ± 0.2674 KPa was acquired when the power was set to 100 W, the interval time was set to 2000 ms, and the terminal impedance was set to 50 Ω. Moreover, the thermal damage range increased with an increase in power but decreased with an increase in the interval time and terminal impedance. Furthermore, the thermal damage range and temperature were presumably related. For an small intestine tissue, the appropriate control parameters could be set when the power was approximately 100 W, the interval time was approximately 2000 ms, and the terminal impedance was approximately 50 Ω. This study could provide a basis for the selection of control parameters for intestinal tissue fusion.
开发了一种用于射频诱导肠组织融合的控制算法,以探索不同控制参数对肠组织融合的影响。在小肠组织上进行射频诱导融合,通过改变算法中的控制参数(功率、间隔时间和终端阻抗)来观察对融合的影响。使用爆破压力和热损伤测量来评估融合质量。组织学评估用于间接评估融合质量。当功率设置为 100W、间隔时间设置为 2000ms 和终端阻抗设置为 50Ω 时,获得的最大爆破压力为 8.460±0.2674kPa。此外,随着功率的增加,热损伤范围增加,而随着间隔时间和终端阻抗的增加,热损伤范围减小。此外,热损伤范围和温度可能相关。对于小肠组织,当功率约为 100W、间隔时间约为 2000ms 和终端阻抗约为 50Ω 时,可以设置适当的控制参数。本研究可为肠组织融合的控制参数选择提供依据。