Westmead Clinical School, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia.
Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Clin Exp Ophthalmol. 2020 Apr;48(3):366-401. doi: 10.1111/ceo.13702. Epub 2020 Jan 22.
Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the types of periocular steroid delivery, their clinical applications in ophthalmology and their side effects.
局部皮质类固醇在眼科治疗炎症性疾病方面有着悠久的历史。前节疾病倾向于用局部皮质类固醇治疗，而后节疾病通常需要眶周、玻璃体内或全身给药以穿透。近几十年来，眶周皮质类固醇给药的临床应用已扩展到多种疾病，包括视网膜血管疾病引起的黄斑水肿。各种制剂的开发旨在提供实用、靶向、长期和更有效的治疗，同时最小化副作用。本文全面概述了眶周皮质类固醇给药的类型、在眼科中的临床应用及其副作用。
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